نتایج جستجو برای: deep brain stimulation dbs
تعداد نتایج: 888101 فیلتر نتایج به سال:
Huntington's disease (HD) is an inherited neurodegenerative disorder clinically characterized by involuntary movements, cognitive decline, and behavioral changes. The complex constellation of clinical symptoms still makes the therapeutic management challenging. We evaluated effects deep brain stimulation (DBS) on patients affected HD, providing a critical outlook achieved results possible devel...
Background: Computer models have previously been used for investigation of deep brain stimulation (DBS) to explore the relation between the stimulation field and the response to stimulation [1-4]. We have previously presented ELMA [3, 5], a patient-specific modelling and simulation method for DBS (Fig. 1). A brain tissue model is built based on the patient’s own magnetic resonance imaging (MRI)...
Background: Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. However, the underlying mechanism of action of DBS remains unknown. The effect of DBS has been studied primarily by direct neural recording studies, which lack the ability to elucidate DBS related responses on a whole-brain scale. Functional Magnetic Resonance Imaging (fMRI) reflects ch...
Recent studies in patients with treatment-resistant depression have shown similar results with the use of deep brain stimulation (DBS) in the subcallosal cingulate gyrus (SCG), ventral capsule/ventral striatum (VC/VS) and nucleus accumbens (Acb). As these brain regions are interconnected, one hypothesis is that by stimulating these targets one would just be influencing different relays in the s...
BACKGROUND The long-term safety of deep brain stimulation (DBS) is an important issue because new applications are being investigated for a variety of disorders. Studying instances where DBS was inadvertently implanted in patients without a movement disorder may provide information about the safety of the therapy. We report the case of a patient with a psychogenic movement disorder treated with...
Deep brain stimulation (DBS) has shown promise for treating a range of brain disorders and neurological conditions. One recent study showed that DBS in the entorhinal region improved the accuracy of human spatial memory. Based on this line of work, we performed a series of experiments to more fully characterize the effects of DBS in the medial temporal lobe on human memory. Neurosurgical patien...
BACKGROUND Recent interest has demonstrated the nucleus accumbens (NAcc) as a potential target for the treatment of depression with deep brain stimulation (DBS). OBJECTIVE To demonstrate that DBS of the NAcc is an effective treatment modality for depression and that chemical and structural changes associated with these behavioral changes are markers of neuroplasticity. METHODS A deep brain ...
Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The peduncul...
Deep brain stimulation (DBS) is an effective clinical treatment for several medically refractory neurological disorders. However, even after decades of clinical success, explicit understanding of the response of neurons to applied electric fields remains limited, and scientific definition of the therapeutic mechanisms of DBS remains elusive. In addition, it is presently unclear which electrode ...
Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson's disease and shows great promise for numerous other disorders. While the fundamental purpose of DBS is to modulate neural activity with electric fields, little is known about the actual voltage distribution generated in the brain by DBS electrodes and as a result it is difficult to accurately predict which br...
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