Health economic decision models are subject to various forms of uncertainty, including uncertainty about the parameters of the model and about the model structure. These uncertainties can be handled within a Bayesian framework, which also allows evidence from previous studies to be combined with the data. As an example, we consider a Markov model for assessing the cost-effectiveness of implanta...

The present study tested several predictions of a context-sensitivity panic vulnerability model emphasizing the interaction between threat context and threat sensitivities. Participants without a history of panic (N=47) completed both global and domain-specific panic relevant sensitivity measures and were then randomized to undergo a 35% CO2 inhalation challenge in the presence or absence of a ...

Our patient was an 85-year-old man who had experienced an out-of-hospital cardiac arrest in September 1990 and subsequently underwent the implantation of an automatic implantable cardioverter-defibrillator as part of the Cardiac Arrest in Seattle: Conventional versus Amiodarone Drug Evaluation (CASCADE) trial, as well as bypass surgery in Seattle, Wash. The defibrillator was placed abdominally....

The first concept of an implantable defibrillator was published in 1970 by Dr. Michel Mirowski and his colleague and friend Dr. Morton Mower. Within 30 years implantable defibrillator therapy has gone through a breathtaking development. However, it started with a vision and a concept of one man, who went through difficult times, personally, and in his intention to make his idea of a device that...

INTRODUCTION The SonR signal has been shown to reflect cardiac contractility. It is recorded with an atrial lead connected to a cardiac resynchronization therapy defibrillator. For the first time, clinical evidence on the use of the SonR signal in the monitoring of the clinical status of heart failure patients implanted with cardiac resynchronization therapy defibrillator are presented through ...

antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the cardiac arrest study hamburg (CASH). Circulation 2000;102:748–754. 9. Daubert JP, Sesselberg HW, Huang DT. Implantable cardioverterdefibrillators for primary prevention: how do the data pertain to the aged? Am J Geriatr Cardiol 2006;15:88–92. 10. Wilkoff BL, Cook JR, Epstein AE, Greene ...

Ventricular arrhythmias are one of the most common causes of death in developed countries. The use of implantable cardiac defibrillators is the most effective treatment to prevent sudden cardiac death. To date, the ejection fraction is the only approved clinical variable used to determine suitability for defibrillator placement in subjects with heart failure. The purpose of this study was to as...

Although feasibility and efficacy of percutaneous tricuspid valve-in-valve implantation have been established, a transtricuspid pacing or defibrillator lead might preclude this technique: lead damage can cause lead dysfunction resulting in inappropriate or inefficient pacing or shocks. In these cases, lead removal is thought to be the only option. We describe a patient who presented with rapid ...

OBJECTIVE Traditional cost-utility analysis assumes that all benefits from health-related interventions are captured by the quality-adjusted life-years (QALYs) gained by the few individuals whose outcome is improved by the intervention. However, it is possible that many individuals who do not directly benefit from an intervention receive utility, and therefore QALYs, because of the passive bene...