Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...

experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...

introduction: demyelination is one of the main causes of neurological disability. it is the end product of numerous pathological processes, multiple sclerosis (ms) being the most common cause. more than 70% of the ms patients suffer from optic disturbances. this disease commonly affects the optic pathway, particularly the optic nerves and chiasm. several attempts have been made to produce a sui...

Four out of seven research workers into swayback disease, a neurological disease of lambs, developed symptoms and signs of multiple sclerosis, and were reported in 1947. A further worker later joined the group. All of the original seven have died and two at necropsy had multiple areas of demyelination in the brain and spinal cord. The chance of four or more out of a random group of eight men de...

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

The differential diagnosis between multiple sclerosis and acute disseminated encephalomyelitis has major prognostic and therapeutic implications for the patient. As originally defined, acute disseminated encephalomyelitis is an acute monophasic disease that requires early anti-inflammatory treatment, whereas long-term immunomodulatory therapies are considered unnecessary due to the self-limitin...

background: the cuprizone multiple sclerosis (ms) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. it has been shown that green tea epigallocatechin-3-gallate (egcg) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. objective...

BACKGROUND Several studies have reported lower focal demyelination and inflammatory activity in primary progressive multiple sclerosis (PPMS) than in relapsing-remitting MS (RRMS). However, very little is known about possible differences in damage and distribution that may occur within lesions visible on magnetic resonance imaging in the 2 forms of the disease. OBJECTIVE To evaluate differenc...

Introduction. Multiple sclerosis is a chronic, inflammatory disease of the central nervous system characterized by areas with changes associated demyelination. Cholesterol significant structural component incorporated into myelin sheath. The aim study was to examine values lipid status parameters in patients multiple and correlation between these triglyceride glucose index. Material Methods. A ...