نتایج جستجو برای: dendritic cell based vaccine

تعداد نتایج: 4502938  

Journal: :avicenna journal of medical biotechnology 0

background: it seems that the success of vaccination for cancer immunotherapy such as dendritic cell (dc) based cancer vaccine is hindered through a powerful network of immune system suppressive elements in which regulatory t cell is the common factor. foxp3 transcription factor is the most specific marker of regulatory t cells. in different studies, targeting an immune response against regulat...

Journal: :iranian journal of immunology 0
saeid abediankenari department of microbiology and immunology, mazandaran university of medical sciences, sari, iran yousef yousedzadeh department of microbiology and immunology, mazandaran university of medical sciences, sari, iran hossein azadeh department of microbiology and immunology, mazandaran university of medical sciences, sari, iran mohammad vahedi department of microbiology and immunology, mazandaran university of medical sciences, sari, iran

background: dendritic cells (dcs) are professional antigen presenting cells that have an important role in the initiation of immune response. the use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. objective: in this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and cpg oligonucleotides in inducing d...

2016
Matthew R Collinson-Pautz Kevin M Slawin Jonathan M Levitt David M Spencer

Therapeutic DNA-based vaccines aim to prime an adaptive host immune response against tumor-associated antigens, eliminating cancer cells primarily through CD8+ cytotoxic T cell-mediated destruction. To be optimally effective, immunological adjuvants are required for the activation of tumor-specific CD8+ T cells responses by DNA vaccination. Here, we describe enhanced anti-tumor efficacy of an i...

2010
Mayu O. Frank Julia Kaufman Suyan Tian Mayte Suárez-Fariñas Salina Parveen Nathalie E. Blachère Michael J. Morris Susan Slovin Howard I. Scher Matthew L. Albert Robert B. Darnell

BACKGROUND Studies of patients with paraneoplastic neurologic disorders (PND) have revealed that apoptotic tumor serves as a potential potent trigger for the initiation of naturally occurring tumor immunity. The purpose of this study was to assess the feasibility, safety, and immunogenicity of an apoptotic tumor-autologous dendritic cell (DC) vaccine. METHODS AND FINDINGS We have modeled PND ...

2013
Gerty Schreibelt Kalijn F. Bol Erik HJG Aarntzen Winald R Gerritsen Cornelis JA Punt Carl G Figdor I Jolanda M de Vries

Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.

2013
Peter M. Ferguson Angela Slocombe Richard D. Tilley Ian F. Hermans

Cancer immunotherapy with antigen-loaded dendritic cell-based vaccines can induce clinical responses in some patients, but further optimization is required to unlock the full potential of this strategy in the clinic. Optimization is dependent on being able to monitor the cellular events that take place once the dendritic cells have been injected in vivo, and to establish whether antigen-specifi...

Ali Akbar Pourfathoolah Ardeshir Ghavamzadeh Kamran Alimoghadam Mahin Nikougoftar Nahid Naderi Seyed Mohammad Moazzeni,

Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation.   Objectives: The aim of this stud...

Journal: :Acta medica Iranica 2013
Saeid Abediankenari Ghasem Janbabaei Mollae Maryam Ghasemi Yousef Yousefzadeh Masoud Bahrami Kamran Alimoghaddam

Dendritic cells (DCs) are professional antigen presenting cells that have a potential role in the initiating of immune responses. The cell vaccination is a new strategy in treatment of infectious diseases and cancers. In this study, we have generated monocyte-derived dendritic cells of lymphoma patient's peripheral blood mononuclear cells then; these cells were used as vaccine in lymphoma patie...

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