BACKGROUND We used an in vitro tooth development model to investigate the effects of overactivation of the Wnt/β-catenin pathway during odontogenesis by bromoindirubin oxime reagent (BIO), a specific inhibitor of GSK-3 activity. RESULTS Overactivating the Wnt/β-catenin pathway at tooth initiation upregulated and ectopically expressed the epithelial markers Sonic Hedgehog (Shh), Epiprofin (Epf...

This study was designed to explore the relationship of the growth of the maxilla and dental arch with different sizes of the denudation area on the hard palate. We tested the hypothesis that different sizes of denudation areas on the hard palate following palatoplasty would significantly influence the growth of the maxilla and dental arch differently. Fifty-one three-week-old Sprague-Dawley mal...

OBJECTIVE Angiogenesis is a key step in the dental pulp healing sequence which involves the dentine bridge formation. In a previous work, we showed that dental pulp cells secrete soluble factors which interact with endothelial cells and affect the process of angiogenesis. The objective of this work was to quantify the angiogenic growth factors released by mechanically injured human dental pulp ...

BACKGROUND The aim of this study is to determine the best surgical/orthodontic treatment plan for the complete bilateral and unilateral cleft lip and palate patient to achieve all treatment goals of facial aesthetics, speech, dental function, and psychosocial development. METHODS Review of 40 years of serial complete bilateral cleft lip and palate and complete unilateral cleft lip and palate ...

BACKGROUND Whether skeletal effects are obtained by functional appliances in class II subjects is still controversial. In this regard, most of the available studies did not clearly identify the growth phases (i.e. pubertal or not) of the treated patients. This retrospective controlled study aimed at evaluating the skeletal and dental changes in class II subjects produced by the functional regul...

s: Background: Giving birth to infants of low birth weight (LBW) (less than 2,500 grams) is a major public health problem worldwide. In an attempt to identify modifiable risk factors for LBW in Saudi Arabia, the present research was undertaken to investigate a potential association between maternal dental health and dental care during pregnancy with LBW due to fetal growth retardation. Material...

Mentoring of students to assist them in the transition to clinical practice has been utilized in a number of health professions but has only been recently introduced in dental and dental hygiene education. A survey was sent to all U.S. dental hygiene program directors to determine the prevalence of mentoring programs in the dental hygiene curriculum that utilize practicing dental hygienists as ...

Dihydropyrimidinase-related protein 4 (Dpysl4) is a known regulator of hippocampal neuron development. Here, we report that Dpysl4 is involved in growth regulation, polarization and differentiation of dental epithelial cells during tooth germ morphogenesis. A reduction in Dpysl4 gene expression in the tooth germ produced a loss of ameloblasts, resulting in the decrease of synthesis and secretio...

OBJECTIVES This study was attempted to incorporate an antibacterial monomer, methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB), into a commercial dental adhesive and to evaluate the antibacterial activity of the DMAE-CB-incorporated adhesive after being cured against Streptococcus mutans. METHODS DMAE-CB was incorporated at 3% (w/v) into a clinically used dental adhesive, Single B...

BACKGROUND To determine the association between the thickness of masseter muscle and the maxillary dental arch width. To explore the influence of gender on masseter muscle thickness. MATERIALS & METHODS Seventy subjects (35 females and 35 males) of age 18 to 25 years were selected for the study based on class I molar relationship. The masseter muscle thickness of the right and left sides in e...