severe traumatic injuries to immature teeth often cause damage to periodontal ligament as well as dental pulp; pulp necrosis, root resorption and subsequent apical lesion are common consequences. this article reports the surgical management of an infected immature maxillary central incisor associated with a gigantic periradicular lesion and severe root resorption. the tooth had a history of tra...

background and aims. the aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (dpc) with calcium hydroxide [ca(oh)2] and simvastatin as pulp-capping materials in the primary human molars. materials and methods. 120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. group ι as a control, u...

Dental Caries affects approximately 90% of the world's population. At present, the clinical treatment for dental caries is root canal therapy. This treatment results in loss of tooth sensitivity and vitality. Tissue engineering can potentially solve this problem by enabling regeneration of a functional pulp tissue. Dental pulp stem cells (DPSCs) have been shown to be an excellent source for pul...

A more refined diagnosis tends to be based on subtle signs and symptoms, requiring the specialist to be extremely judicious and knowledgeable. Occlusal trauma should be included in the differential diagnosis of apical periodontitis and dental trauma. Ideally, when a tooth presents with pulp necrosis and signs of occlusal trauma, one should conduct the interview and diagnostic tests in search of...

Acute dental pain most often occurs in relation to inflammatory conditions in the dental pulp or in the periradicular tissues surrounding a tooth, but it is not always easy to reach a diagnose and determine what treatment to perform. The anamnesis and the clinical examination provide valuable information, and a systematic approach is necessary. This paper will focus on diagnosis and treatment o...

stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

Human dental pulp cells (HDPCs) play a crucial role in dental pulp inflammation. Pannexin 3 (Panx3), a member of Panxs (Pannexins), has been recently found to be involved in inflammation. However, the mechanism of Panx3 in human dental pulp inflammation remains unclear. In this study, the role of Panx3 in inflammatory response was firstly explored, and its potential mechanism was proposed. Immu...

Pulp vitality is extremely important for the tooth viability, since it provides nutrition and acts as biosensor to detect pathogenic stimuli. In the dental clinic, most dental pulp infections are irreversible due to its anatomical position and organization. It is difficult for the body to eliminate the infection, which subsequently persists and worsens. The widely used strategy currently in the...

Chemical decomposition and fragmentation may limit the detection of ancient host and microbial DNA while some proteins can be detected for extended periods of time. We applied paleoproteomics on 300-year-old dental pulp specimens recovered from 16 individuals in two archeological funeral sites in France, comprising one documented plague site and one documented plague-negative site. The dental p...

To elucidate the dental pulp-representing area in the human primary somatosensory cortex and the presence of A-beta fibers in dental pulp, we recorded somatosensory-evoked magnetic fields from the cortex in seven healthy persons using magnetoencephalography. Following non-painful electrical stimulation of the right maxillary first premolar dental pulp, short latency (27 ms) cortical responses o...