hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. nucleated rbcs give rise to spuriously high total leucocyte count and cause clinical dilemma. thalassemia major patients are known to have leucocytosis even after correction for nucleated rbcs. we report a case of undiagnosed thalassemia major in a 4 month old infant with total leucocyte count highe...

pulmonary arterial hypertension (pah) is a progressive disease with high morbidity and mortality rates. research has shown that pah has a prevalence rate of 10-79% in thalassemia major patients. this cross-sectional study was carried out in 2014 to determine the prevalence and risk factors of pah in all thalassemia major patients of over 18 years of age in ilam, iran. a cardiologist measured sy...

background: one of the most common endocrine problems in major beta-thalassemia is hypothyroidism (ht). the aim of this study was to evaluate thyroid function status in major beta-thalassemia patients older than 10 years old. methods: this cross sectional study was carried out on thalassemia major patients registered on thalassemia center of amirkola children hospital in babol. a questionnaire ...

abstract introduction: thalassemia is the most common hereditary anemia in iran. the aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins igg, igm, and iga and complement components in patients with major thalassemia. materials and methods: this interventional semi-experimental study (before-after) was performed o...

peripheral blood t lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. three monoclonal antibodies (anti-cd3, anti cd-f, unti-cds) were simultaneously applied for detection of th (cd3-, cd4^), tsk (cd3+, cd8+) and th/ts ratio by flow-cytometry respectively. the results of this study sho...

INTRODUCTION Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia. MATERIALS AND METHODS We ordered following tests for consideration endocrine abnormalities: fasting plasma glucos...

Hemoglobin E (HbE; alpha2beta226glu-lys), globally the commonest hemoglobin variant, is synthesized at a slightly reduced rate and has a homozygous phenotype similar to heterozygous beta thalassemia. Yet, when it is inherited together with a beta thalassemia allele, the resulting condition, HbE/beta thalassemia, is sometimes characterized by a severe, transfusion-dependent thalassemia major. Th...

during the last two decades conventional therapy has improved the prognosis of thalassemia. however, despite such improvement it still remains a progressive disease with treatment-related complications such as hepatitis, liver fibrosis, and cardiac disease. bone marrow transplantation (bmt) can prevent or delay progression of the aforementioned complications. the importance of clinical research...

introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...