The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming ...

Abstract. Background Depression is a mood disorder that affects person’s quality of life. This condition influenced by the levels monoamine compounds such as serotonin, norepinephrine, and dopamine in brain. The decrease leads to depressive symptoms. Lemon peel essential oil has an antidepressant potential, contains phytochemicals, d-Limonene, which increase Aromatherapy diffuser inhalation met...

BACKGROUND Extracts of the plant Hypericum perforatum L. have been traditionally used in folk medicine for the treatment of depressive disorders. Xanthone, a component of Hypericum perforatum L., has been shown to be effective in animal models of depression. OBJECTIVE We investigated if 2 xanthone derivatives (1101 and 1105) were as effective as venlafaxine, which is a serotonin-norepinephrin...

Objective: The objective was to evaluate depressant effects on central nervous system (CNS) and behavioral of ethanol extract clitoria annua find the phytochemical responsible for these activities with possible mode action. Materials & Method: activity C. evaluated by classical models depression as Rota rod method, Actophotometer test, tail suspension, thiopental sodium induced sleeping tim...

CONTEXT In traditional system of medicine brahmi has been used to enhance memory. Recently it has been reported to have action in psychiatric disorders. With these backgrounds the work has been undertaken to study antidepressant activity of brahmi in albino mice. AIM To evaluate antidepressant activity of brahmi in experimental models. MATERIALS AND METHODS The antidepressant activity was s...

Background: The present study was designed to investigate the effect of citalopram, ketamine, glycine and their combinations on animal models depression. Methods: Swiss Albino male mice were subjected chronic mild stress for 6 weeks inducing depression, randomly divided into different groups: citalopram (5 10 mg/kg), ketamine (17.5 35 (50 100 mg/kg) + mg/kg). Two behavioural tests utilized asse...

Background Zuotai, a famous Tibetan medicinal mixture containing metacinnabar, is traditionally used for the purpose of tranquilizing minds and soothing nerves. However, it still lacks substantial experimental data for it to be approved for use. Aim This study was designed to assess the effects of Zuotai on depressive-like symptoms in a chronic unpredictable mild stress (CUMS) mouse model, an...

The increasing use of mobile phones by teenagers has raised concern about the cognitive effects of radiofrequency (RF) fields. In this study, we investigated the effects of 4-week exposure to a 1.8 GHz RF field on the emotional behavior and spatial memory of adolescent male mice. Anxiety-like behavior was evaluated by open field test (OFT) and elevated plus maze (EPM) test, while depression-lik...

Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the en...

Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 st...