The aim of this study was to investigate whether conditional inactivation of the glucocorticoid receptors (GRs) in noradrenergic neurons affects animal behavior in mice. Selective ablation of GRs in the noradrenergic system was achieved using the Cre/loxP approach. We crossed transgenic mice expressing the Cre recombinase under the dopamine beta-hydroxylase (DBH) promoter with animals harboring...

Chronic exposure to light at night (LAN) is a circadian disruptor and may be linked to various health risks, including mood disorders. We recently demonstrated that chronic exposure to dim (5 lux) LAN provokes depressive-like behaviors and reduced hippocampal CA1 dendritic spine density in female hamsters. Whether this model is responsive to selective serotonin reuptake inhibitors remains unspe...

Adolescence is a vulnerable period which is associated with a heightened risk for the development of depressive disorders. Risk-behaviors like alcohol or illicit drug abuse, excessive use of media, school absenteeism and lack of sleep are also frequently occurring during this period; it is often suggested that such behaviors may be associated with mental health problems. This article includes a...

Research clearly demonstrates that parents pass risk for depression and antisocial behavior on to their children. However, most research confounds genetic and environmental mechanisms by studying genetically related individuals. Furthermore, most studies focus on either depression or antisocial behavior in parents or children, despite evidence of co-occurrence and shared etiology, and few consi...

our ancestors without fear, worry and anxiety are not our ancestors, as organisms without defense systems were extinct. therefore, while behavior such as fear and anxiety are useful to prevent harm, the exaggerated form, that is, anxiety disorders, has more costs than benefits. likewise, while a panic attack is a normal and useful response in the face of life-threatening danger, a panic disorde...

A mechanism-based model was developed to describe the time course of lipopolysaccharide-induced depressive-like behavior and azithromycin pharmacodynamics in mice. The lipopolysaccharide-induced disease progression was monitored by lipopolysaccharide, proinflammatory cytokines, and kynrenine concentration in plasma. The depressive-like behavior was investigated by forced swimming test and tail ...

The relation of marital complaints to family history was examined in a sample of 1,624 psychiatric outpatients. Marital complaints were recognized to be an aspect of a broader "depressive spectrum disorder" with distinctive age, gender, alcohol, and neurotic depressive symptom characteristics; however, holding constant the depressive spectrum characteristics, a specific independent relation of ...

VERBAL BEHAVIOR IN INDIVIDUALS WITH GENERALIZED ANXIETY DISORDER AND DEPRESSIVE DISORDERS

VERBAL BEHAVIOR IN INDIVIDUALS WITH GENERALIZED ANXIETY DISORDER AND DEPRESSIVE DISORDERS