BACKGROUND Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. METHODS Twenty-seven patients were started on agomelatine (25mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels w...

Purpose: To determine the inhibitory effect of curcumin on expression brain-derived neurotrophic factor (BDNF) in hippocampus mice with sleep deprivation.
 Methods: Expressions BDNF and miRNA-206 were evaluated using quantitative real time-polymerase chain reaction (qRT-PCR) a sleep-deprived mouse model. Interaction was assessed by dual luciferase qPCR) assays. The also determined qRT-PCR....

Gilland, Kaitlyn Elizabeth. M.S., Purdue University, May 2016. Short-Term Effects of a Western Diet on the Number of Brain-Derived Neurotrophic Factor Immunoreactive Neurons in the Hypothalamic Arcuate, Ventromedial and Paraventricular Nuclei. Major Professor: Edward Fox. Brain-derived neurotrophic factor (BDNF) is an important anorexogenic factor and has been shown to be involved in obesity. I...

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are neuronal survival molecules which utilize the Trk family of tyrosine kinase receptors. Using double-label in situ hybridization, we demonstrate that mRNAs for BDNF and its high-affinity receptor TrkB are coexpressed in hippocampal and cortical neurons. Also, a large number of neurons in these areas coexpress NGF and BDNF...

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. We have generated bacterial artificial chromosome (BAC) transgenic mice harboring 207 kb of the rat BDNF (rBDNF) locus containing the gene, 13 kb of genomic sequences upstream of BDNF exon I, and 144 kb downst...

Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological pain states, and exogenous BDNF and GDNF have multiple effects on pain behavi...

To explore the effect of electroacupuncture on spinal cord injury (SCI) involving immune-related factors and regeneration-related in rats. The model contusion was established by PCI 3000 instrument. Two types acupuncture points were selected for treatment rats tested once a week, fiber remodeling detected magnetic resonance imaging. Transcriptome sequencing performed scar samples. Using Python ...

Glial cell line-derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively labelled exogenous GDNF is retrogradely transported from neonatal teeth and vibrissae to the trigeminal neurons, indicating that GDNF acts as a classical neurotrophic factor in the trigeminal system. We also show t...

Food intake is intricately regulated by glucose, amino acids, hormones, neuropeptides, and trophic factors through a neural circuit in the hypothalamus. Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor in the brain, regulates differentiation, maturation, and synaptic plasticity throughout life. Among its many roles, BDNF exerts an anorexigenic function in the bra...