OBJECTIVES To evaluate the clinical outcome of the first 450 consecutive cases after Descemet membrane endothelial keratoplasty (DMEK), as well as the effect of standardization of the technique. MATERIAL AND METHODS Comparison between 3 groups: Group I: (cases 1-125), as the extended learning curve; Group II: (cases 126-250), transition to technique standardization; Group III: (cases 251-450)...

During a wound-healing cell migration assay experiment, cells are observed to detach and undergo mitosis before reattaching as a pair of cells on the substrate. During experiments with mice 3T3 fibroblasts, cell detachment can be confined to the wavefront region or it can occur over the whole wave profile. A multi-species continuum approach to modelling a wound-healing assay is taken to account...

Atomic force microscopy has been used to investigate the detachment of single polymer chains from surfaces and to measure the picoNewton forces required to extend the chain orthogonal to the surface. Such recent experiments show that the force-extension profiles provide interesting signatures which might be related to the progressive detachment of the chain from a surface. Using equilibrium sca...

Motivated by the need for understanding the boiling processes in three-phase microscopic systems, the present work aims to uncover the physics of forced dewetting of a liquid film initially attached to a metal wire frame, which is heated with a rate up to O(108) K s−1 by discharging a capacitor impulsively. Depending on the corresponding heat flux O(1011) J m−2, there are several key dewetting ...

OBJECTIVES A study reported a significant association between oral fluoroquinolones and the development of retinal detachment among current users of oral fluoroquinolones (Etminan M, Forooghian F, Brophy JM et al. JAMA 2012; 307: 1414-9). However, other published studies have discordant results. This study aimed to investigate this association and to estimate the absolute risk of developing ret...

A suite of techniques was utilized to evaluate the correlation between biofilm physiology, fluid-induced shear stress, and detachment in hollow fiber membrane aerated bioreactors. Two monoculture species biofilms were grown on silicone fibers in a hollow fiber membrane aerated bioreactors (HfMBR) to assess detachment under laminar fluid flow conditions. Both physiology (biofilm thickness and ro...

a dog was presented with history of progressive generalized subcutaneous emphysema and exercise intolerance secondary to dog fight. radiographic evaluation confirmed extensive subcutaneous emphysema, pneumomediastinum and pneumoretroperitoneum. surgical exploration revealed cricoid cartilage longitudinal fracture and cricotracheal detachment. the fractured cartilage was sutured and the cricoid ...

PURPOSE Based on current evidence, the efficiency and safety of Descemet's membrane endothelial keratoplasty (DMEK) was compared with that of Descemet's stripping endothelial keratoplasty (DSEK). METHODS Pubmed, Embase, Web of Science, the Cochrane Database and conference abstracts were comprehensively searched for studies that compared the efficacy and safety of DMEK and DSEK. The efficacy o...

Kinesin is a processive motor protein: A single molecule can walk continuously along a microtubule for several micrometers, taking hundreds of 8-nm steps without dissociating. To elucidate the biochemical and structural basis for processivity, we have engineered a heterodimeric one-headed kinesin and compared its biochemical properties to those of the wild-type two-headed molecule. Our construc...

This paper deals with the effects of mixing time on the homogeneity and dispersion performance of adhesive mixtures for inhalation. Interactions between these effects and the carrier size fraction, the type of drug and the inhalation flow rate were studied. Furthermore, it was examined whether or not changes in the dispersion performance as a result of prolonged mixing can be explained with a b...