The implementation of thyroid hormone (T3) or glucagon as lipid-lowering, antidiabetic, and antiobesity agents have not been successful to date because of serious adverse side effects. Using a synthetic hybrid glucagon/T3 conjugate, Finan et al have established a novel therapeutic approach for the reversal of dyslipidemia, obesity, and insulin resistance associated with the metabolic syndrome, ...

We extend Condorcet’s Jury Theorem (Essai sur l’application de l’analyse à la probabilité des décisions rendues à la pluralité des voix. De l’imprimerie royale, 1785) to weighted voting games with voters of two kinds: a fixed (possibly empty) set of ‘major’ voters with fixed weights, and an ever-increasing number of ‘minor’ voters, whose total weight is also fixed, but where each individual’s w...