The N-methyl-D-aspartate receptor plays an important role in central sensitization of neuropathic pain and N-methyl-D-aspartate receptor antagonists, such as ketamine, memantine and dextromethorphan may be used for persistent pain. However, ketamine cannot be repeated too often because of its adverse events. A drug relay would be helpful in the outpatient to postpone or even cancel the next ket...

BACKGROUND AND OBJECTIVE Dextromethorphan/quinidine (DMQ) is the first agent indicated for the treatment of pseudobulbar affect. Dextromethorphan, the active ingredient, is a low-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. This study evaluated the potential for a drug-drug interaction (DDI) of DMQ with memantine, which is also an NMDA receptor antagonist. METHODS ...

In this study, 40 zebrafish embryos were raised in various Robitussin solutions (0.02 mg/mL, 0.002mg/mL, 0.0002mg/mL, instant ocean control) to determine the effects the common ingredient dextromethorphan (found in many over-the-counter medicines) had on the development of fish. Previous studies on the effects dextromethorphan on humans have been conducted, and results have found that the commo...

Using proton and phosphorus magnetic resonance spectroscopy, we evaluated the metabolic effects of preischemic administration of the N-methyl-D-aspartate antagonist dextromethorphan (50 mg/kg i.p.) during global forebrain ischemia and subsequent reperfusion in rats. Dextromethorphan-treated animals (n = 10) showed less lactate formation during ischemia than untreated animals (n = 11, p less tha...

BACKGROUND Dextromethorphan (DM), the D-isomer of the codeine analogue levorphanol, is a weak, noncompetitive N-Methyl-D-Aspartate (NMDA) receptor antagonist. It has been suggested that NMDA receptor antagonists induce preemptive analgesia when administrated before tissue injury occurs, thus decreasing the subsequent sensation of pain. METHOD The study was conducted in the Dr. Ali Shariati Ho...

Aims: New validated method for the simultaneous estimation of Bupropion and Dextromethorphan using HPLC.
 Place Duration Study: Department Chemistry, RVR & JC College Engineering, Chowdavaram, Guntur, Andhra Pradesh, between July 2022 August 2022.
 Methodology: Using Inertsil ODS 250 x 4.6 mm, 5 µm column, acetonitrile 0.1 percent formic acid (30:70 v/v) as a mobile phase, propose...

A rapid, simple and direct assay procedure based on first-derivative spectrophotometry, using a zero-crossing and peak-to-base measurement at 234 and 324 nm, respectively, has been developed for the specific determination of dextromethorphan HBr and bromhexine HCl in tablets. Calibration graphs were linear with the correlation coefficients of 0.9999 for both analytes. The limit of detections we...

Genetically determined individual differences in the ability to oxidize certain drugs have raised recently a considerable interest because of clinical importance of this problem. Determination of CYP2D6 oxidation phenotype is used to obtain more efficient pharmacotherapy and to explain lower efficacy of some drugs and presentation of adverse effects in particular patients. The aim of this study...