To determine the relative expression of distinct mucin genes in normal and neoplastic tissue, antibodies and cDNA probes that recognize the core tandem repeat sequences of membrane-bound (MUC1) and secreted (MUC2 and MUC3) mucins were used for immunohistochemical and RNA Northern and slot-blot analysis. MUC1 mRNA was detected in all epithelial tissues tested. MUC1 core peptide, recognized by mo...

The aim of this study was to analyze whether a monoclonal antibody to human milk fat globule membrane-associated antigens, recognized specifically and homogeneously by human breast carcinoma cells but also by normal epithelial cells active in secretion, could be used to restrict the access of antitumoral drugs to cells exposing the epitope. The drug-antibody conjugate to be used is constructed ...

toneal mesothelium predominantly express the 90-kDa CD44H mol ecule, whereas ovarian cancer lines that bind poorly to mesothelium express either absent or relatively low levels of CD44H (2, 3). Furthermore, transfection of weakly binding ovarian cancer cells with CD44H cDNA is capable of restoring their ability to bind to mesothe hum in vitro (3). Finally, treatment of mesothelial monolayers wi...

Breast cancer metastasis accounts for the majority of deaths from breast cancer. Detection of breast cancer metastasis at the earliest stage is important for the management and prediction of breast cancer progression. Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. Ad...

The aim of this study was to analyze whether a monoclonal antibody to human milk fat globule membrane-associated antigens, recognized specifically and homogeneously by human breast carcinoma cells but also by normal epithelial cells active in secretion, could be used to restrict the access of antitumoral drugs to cells exposing the epitope. The drugantibody conjugate to be used is constructed b...

Background: HIV patients have several habits that can produce oral lesions. However, the association of oral habits and risk behaviors with oral and peri-oral lesions in HIV patients has not been studied in Ethiopia to date. Objective: To assess the relationship of oral and peri-oral lesions with oral habits, risk behaviors, socio-demographic factors and clinical stages of disease among HIV inf...

Background: The mucin MUC1, a type I transmembrane glycoprotein, is overexpressed in breast cancer and hasbeen correlated with increased metastasis. We were the first to report binding between MUC1 and Intercellularadhesion molecule-1 (ICAM-1), which is expressed on stromal and endothelial cells throughout the migratory tractof a metastasizing breast cancer cell. Subsequently, w...

În cadrul acestei lucrări sunt explorate soluţii de aplicare a specificaţiilor IEC 61499 în modelarea şi implementarea controlului de nivel înalt al holonilor. Conceptele IEC 61499 au fost utilizate ca o tehnologie suport pentru încapsularea controlului inteligent al holonilor, modelarea comunicaţiei interholonice şi configurarea dinamică a holonilor. Modelele şi teoriile propuse au fost valida...