Aim To analyse the cost-effectiveness of different interventions for Type 2 diabetes prevention within a common framework. Methods A micro-simulation model was developed to evaluate the cost-effectiveness of a range of diabetes prevention interventions including: (1) soft drinks taxation; (2) retail policy in socially deprived areas; (3) workplace intervention; (4) community-based intervention;...

Osteocalcin, the second most abundant protein in bone tissue after collagen, is secreted by osteoblasts and thought to participate in mineralization and calcium ion homeostasis. In addition to its use as biomarker in ostoporosis, experimental studies on mice published in Cell journal revealed for osteocalcin new metabolic functions, as hormone, being involved in blood glucose regulation, in ins...

SCREENING FOR DIABETIC RETINOPATHY Diabetic retinopathy is a highly specific vascular complication of both type 1 and type 2 diabetes. The prevalence of retinopathy is strongly related to the duration of diabetes. After 20 years of diabetes, nearly all patients with type 1 diabetes and >60% of patients with type 2 diabetes have some degree of retinopathy. Diabetic retinopathy poses a serious th...

SCREENING FOR DIABETIC RETINOPATHY Diabetic retinopathy is a highly specific vascular complication of both type 1 and type 2 diabetes. The prevalence of retinopathy is strongly related to the duration of diabetes. After 20 years of diabetes, nearly all patients with type 1 diabetes and >60% of patients with type 2 diabetes have some degree of retinopathy. Diabetic retinopathy poses a serious th...

Contributions from Cori’s laboratory by Colowick et al. (3, 4) and Sutherland (5) have proposed the concept that the effects of certain hormones (from the anterior pituitary, adrenal cortex, and pancreas) in carbohydrate metabolism are iinked with their action on specific tissue enzymes. The action of insulin as thus far uncovered by the above investigators is not simple, and involves in skelet...

References 1 Bright R. Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guy’s Hospital Trans 1836;1:338–79. 2 Jarrett RJ, Keen H, Boyns DR, Chlouverakis C, Fuller J. The concomitants of raised blood sugar: studies in newly detected hyperglycaemics. 1. A comparative assessment of neurological functions in blood sugar groups. Guy’s Hospital ...

Aims Electrocardiographic ventricular repolarization QT parameters are independent risk factors for cardiovascular events and sudden cardiac death in diabetic patients. The aim of the study was to investigate the association of polymorphisms of the nitric oxide synthase 1 adaptor protein (NOS1AP) gene with QT interval in Chinese subjects with or without Type 2 diabetes. Methods Three single nuc...

Aim To assess cholesterol screening of children with Type 1 diabetes by diabetes professionals using a survey of current practice, given that National Institute of Health and Care Excellence guidelines on childhood Type 1 diabetes do not recommend cholesterol screening, yet the National Paediatric Diabetes Audit has an annual cholesterol measure (> 12 years) as a key outcome indicator. Methods ...