BACKGROUND Most evidence suggesting an association between schizophrenia, antipsychotic medications and diabetes has been based on retrospective studies not controlled for important confounders. AIMS To compare diabetogenic risk between antipsychotic medications; and to describe the limitations of current prospective data-sets. METHOD Systematic review of prospective clinical data. RESULT...

The cytotoxic alloxan is the most prominent diabetogenic chemical agent in experimental diabetes research. Alloxan has been found to be selectively toxic to liver hepatocytes. The experiments aim to understand the effect of alloxan on cytomorphology of liver in rat. Treatment with alloxan caused central vein congestion with significant dilatation of sinusoidal spaces. The liver of the alloxan t...