Our understanding of the function of human DNA, known as the human genome, is steadily progressing. Cytogenetic methods have been in clinical use since the 1960s, and molecular tests for almost 2,500 rare monogenic disorders since the 1980s. Recently, genetic testing has also become an important tool in studies of familial cancer predisposition, where the numbers of those benefiting from testin...

The emergence of point-of-care (POC) diagnostics specifically designed for low-resource settings coupled with the rapid increase in need for routine care of patients with chronic diseases should prompt reconsideration of how health care can be delivered most beneficially and cost-effectively in developing countries. Bolstering support for primary care to provide rapid and appropriate integrated...

Industrial diagnostics is an important application area for many AI formalisms. Temporal diagnostics, based on analyzing temporal relations between values of crucial variables, is one possible approach to industrial diagnostics. Often, the information obtained from an industrial object can be uncertain, making the task of diagnostics more complex. In this paper, we propose an approach to tempor...

We discuss three different observational diagnostics related to disks around hot stars: absorption line determinations of rotational velocities of Be stars; polarization diagnostics of circumstellar disks; and X-ray line diagnostics of one specific magnetized hot star, θ Ori C. Some common themes that emerge from these studies include (a) the benefits of having a specific physical model as a fr...

In this paper we describe several diagnostics that we have developed to assist the development of high power gas phase lasers including COIL, EOIL, and DPAL. For COIL we discuss systems that provide sensitive measurements of O2(a), small signal gain, iodine dissociation, and temperature. These are key operational parameters within COIL, and these diagnostics have been used world-wide to gain a ...

Next generation vehicles will provide powerful connectivity and telematics services, enabling many new applications of vehicle communication. We will in this paper study the opportunities of performing remote vehicle diagnostics, where the diagnostic tool (test equipment) and the vehicle are separated by an internetwork, e.g. the Internet. The development of a prototype system for remote vehicl...

Companion diagnostics are an indispensable part of personalized medicine and will likely continue to rapidly increase in number and application to disease areas. The first companion diagnostics were launched in the 1980s and in the face of significant initial skepticism from drug developers as to whether segmenting a drug's market through a diagnostic was advisable. The commercial success of dr...