نتایج جستجو برای: diazoxide
تعداد نتایج: 1114 فیلتر نتایج به سال:
The challenges of achieving optimal glycemic control in type 2 diabetes highlight the need for new therapies. Inappropriately elevated endogenous glucose production (EGP) is the main source of hyperglycemia in type 2 diabetes. Because activation of central ATP-sensitive potassium (KATP) channels suppresses EGP in nondiabetic rodents and humans, this study examined whether type 2 diabetic humans...
BACKGROUND Endothelial dysfunction contributes to ischemia-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC). IPC may involve activation of ATP-sensitive potassium channels (K(ATP)). We determined whether modulation of K(ATP) channels occurs in endothelial IPC in humans. METHODS AND RESULTS IRI of the forearm was induced by inflating a blood pressure cuff to 200 mm Hg ...
Objectives: The mechanism by which the mitochondrial K channel openers confer protection against ischemia / reperfusion injury is ATP debated. Evidence suggests that rather than solely being an end effector, opening of these channels may act by a trigger mechanism. We examined the effects of the mitochondrial K channel opener, diazoxide on parameters of mitochondrial function with specific refe...
The diabetogenic activity of benzothiadiazine drugs has been well established (2). Diazoxide 1 is an antihypertensive agent with potent hyperglycemic activity, particularly when used in combination with trichlormethiazide 2 (3-5). The mode of action by which these compounds exert a temporary diabetogenic effect has not been established. It has been suggested by some that diazoxide-induced hyper...
BACKGROUND Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as "ischemic preconditioning," remains uncertain. Pharmacological evidence has implicated ATP-dependent potassium (KATP) channels in the mechanism of preconditioning; however, the effects of sarcolemmal KATP channels on ex...
Background: Glaucoma refers to a heterogeneous group of diseases characterized by retinal cell degeneration and optic nerve atrophy leading blindness. Even though about 40% patients have normal intraocular pressure (IOP), current treatment. focuses on lowering IOP. With time, drugs become less effective, which has motivated the search for novel drugs.The objective was establish whether modulato...
Hyperinsulinemic hypoglycemia (HH) is the commonest cause of persistent hypoglycemia in the neonatal and infancy periods. Mutations in the ABCC8 and KCNJ11 genes, which encode subunits of the ATP-sensitive potassium channel in the pancreatic beta cell, are identified in approximately 50% of these patients. The first-line drug in the treatment of HH is diazoxide. Octreotide and glucagon can be u...
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