BACKGROUND Diclofenac is a nonsteroidal anti-inflammatory drug used for the treatment of patients with osteoarthritis. OBJECTIVES Our primary objective was to compare bioavailability and tolerability of a generic sustained-release tablet with the established reference sustained-release tablet of diclofenac sodium in a fasting, healthy Chinese male population. METHODS A randomized, open-labe...

Diclofenac sodium and alginate was intercalated into montmorillonite to form uniform sized beads by gelation method. The structure and surface morphology of the synthesized composite beads were characterized by powdered X-ray diffraction, Fourier transform infrared spectroscopy, thermo gravimetric analysis and scanning electron microscopy. Diclofenac release kinetics of the composite in simulat...

BACKGROUND Adaptation of nanotechnology into materials science has also advanced tissue engineering research. Tissues are basically composed of nanoscale structures hence making nanofibrous materials closely resemble natural fibers. Adding a drug release function to such material may further advance their use in tissue repair. METHODS In the current study, bioabsorbable poly(D,L lactide-co-gl...

The aim of this study was to compare analgesic effect of intramuscular (IM) sodium diclofenac and intranasal desmopressin combination with IM sodium diclofenac alone in patients with acute renal colic. In this randomized double-blind clinical trial, all patients aged 18 to 55 years who were diagnosed as acute renal colic and met the inclusion and exclusion criteria were randomized into two grou...

AIM to assess the ability of curcuminoid from Curcuma domestica Val in reducing the cycloxygenase-2 secretion by synovial fluid's monocytes compared to diclofenac sodium in patients with osteoarthritis. METHODS this was a prospective randomized open end blinded evaluation (PROBE) study. The subjects were patients with knee osteoarthritis who were divided randomly into two groups, the first gr...

The formulation and evaluation of diclofenac sodium from liposomes, niosomes and nanoemulsion are analyzed. The release profiles of diclofenac sodium were almost similar in all the formulations. It is found that 85% of diclofenac sodium diffused out from the colloidal systems within 8hrs and practically all the drug was released within 12hrs. In addition to this controlled release, the similari...

Diclofenac Sodium, a non steroidal anti-inflammatory agent is frequently prescribed for the long term treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. The drug undergoes substantial first pass effect and only 50% of drug is available systemically. Further, the drug is known to induce ulceration and bleeding of the intestinal wall. To avoid the adverse effect, altern...

Plasma gelsolin levels significantly decline in several disease conditions, since gelsolin gets scavenged when it depolymerizes and caps filamentous actin released in the circulation following tissue injury. It is well established that our body require/implement inflammatory and analgesic responses to protect against cell damage and injury to the tissue. This study was envisaged to examine anal...

Lyrtzis C, Papadopoulos C, Natsis K, Noussios G. The effect of diclofenac sodium and paracetamol on active and passive range of ankle motion after sprains. J. Hum. Sport Exerc. Vol. 6, No. 1, pp. 40-48, 2011. The purpose of this study was to evaluate the effect of a NSAID, Diclofenac sodium, and an analgesic, Paracetamol in the reduction of pain and in the passive and active range of ankle moti...

A double-blind crossover trial between diclofenac sodium and placebo was carried out in 32 hospitalized patients who were thought to be stabilized on concurrent anticoagulant therapy with acenocoumarol. The object of the trial was to investigate any possible interaction between diclofenac and anticoagulant by monitoring prothrombin times daily through the four week period. No statistically sign...