نتایج جستجو برای: diethylnitrosamine

تعداد نتایج: 1220  

2015
Natalia Sacilotto Josefa Castillo Ángela L. Riffo-Campos Juana M. Flores Olivia Hibbitt Richard Wade-Martins Carlos López M. Isabel Rodrigo Luis Franco Gerardo López-Rodas Matias A Avila

The prognosis of hepatocellular carcinoma patients is usually poor, the size of tumors being a limiting factor for surgical treatments. Present results suggest that the overexpression of Gas1 (growth arrest specific 1) gene reduces the size, proliferating activity and malignancy of liver tumors. Mice developing diethylnitrosamine-induced hepatocellular carcinoma were subjected to hydrodynamic g...

Journal: :Toxicologic pathology 2012
Olga Beltrán-Ramírez Roberto Macías Pérez Adolfo Sierra-Santoyo Saúl Villa-Treviño

Studies of cancer chemoprevention with caffeic acid phenethyl ester (CAPE) in the resistant hepatocyte model of hepatocarcinogenesis have shown the participation of CYP drug metabolizing enzymes. To prevent neoplastic and preneoplasic lesions, we must specifically identify which CYP activities are modified in the mechanism of action of CAPE. Male Fischer-344 rats were pretreated with CAPE twelv...

Journal: :Carcinogenesis 1997
H E van Gijssel C B Maassen G J Mulder J H Meerman

The tumour suppressor gene p53 is expressed in response to DNA-damage; its protein product blocks cells in the G1-phase of the cell cycle. This gives cells additional time to repair their DNA-damage. However, it may trigger apoptosis if damage is too high. Loss of p53 function appears to be an important step in carcinogenesis because 50% of human tumours have lost functional p53. In order to st...

2006
Herschel Sidransky Carleton T. Garrett Challakonda N. Murty Ethel Verney Elizabeth S. Robinson

The ingestion of an elevated level (2%) of t-tryptophan (TRP) in a purified diet was investigated to determine whether it would influence the induction of -y-glutamyltranspeptidase (GGT>positive foci in the livers of rats exposed to a hepatocarcinogen. Subtotal hepatectomies were performed, and 18 h later, the rats were given injections i.p. of diethylnitrosamine (30 mg/kg). Ten days later, gro...

Journal: :Cancer research 1998
A Shimada G Shiota H Miyata T Kamahora H Kawasaki K Shiraki S Hino T Terada

We immunohistochemically analyzed the expression of double-stranded RNA-dependent protein kinase (PKR) using a monoclonal antibody, 71/10. Test samples included 64 human liver biopsies and 25 liver sections of rats inoculated with diethylnitrosamine. The PKR signals in human fatty livers and normal rat livers were minimum. Scoring signal intensity from 0-4, the average scores of chronic active ...

Journal: :Cancer research 1986
H M Rabes L Müller A Hartmann R Kerler C Schuster

Changes in the sensitivity of hepatocytes to initiation during the cell cycle were investigated in partially resected hydroxyurea-synchronized regenerating rat liver. At defined periods of the cell cycle the animals were given injections of a single dose of N-methyl-N-nitrosourea (MNU) (25 mg/kg) and were subsequently exposed to diethylnitrosamine for 30 days (2 mg/kg/day) or to phenobarbital (...

Journal: :Cancer research 1997
V M Factor C Y Kao E Santoni-Rugiu J T Woitach M R Jensen S S Thorgeirsson

Transforming growth factor beta-1 (TGF-beta1) is a potent inhibitor of hepatocyte growth both in vivo and in vitro. In this study, we analyzed the effects of TGF-beta1 on both naturally occurring and diethylnitrosamine-induced hepatocarcinogenesis using single transgenic TGF-beta1 and double transgenic c-myc/TGF-beta1 mice in which the expression of both transgenes was targeted to the liver. He...

Journal: :Cancer research 1989
B K Suchy M Sarafoff R Kerler H M Rabes

c-myc expression, amplification, and rearrangement were studied in neoplastic hepatic nodules of rats after diethylnitrosamine treatment, in hepatocellular carcinomas induced by N-methyl-N-nitrosourea, and in tumorigenic liver cell lines derived from rat hepatocytes transformed by diethylnitrosamine in vivo. Steady-state levels of c-myc transcripts, as measured by Northern blot hybridization, w...

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