The aryl hydrocarbon receptor (AHR) is an environmental sensor and ligand-activated transcription factor that involved in epithelial homeostasis barrier development of the skin. Through genome-wide transcriptomic epigenomic analyses human primary keratinocytes upon AHR activation using TCDD we identified early late responsive genes. genes were enriched for canonical factors known to promote ker...

Background: Mesenchymal stem cells (MSCs) are multipotent cells, capable of differentiating into different cell lines.They can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. Therefore, the exposure of these cells to endothelial growth factor (VEGF) as well as hemodynamic biomechanical forces, which act on...

introduction: type i diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. a new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells. methods: human embryonic stem cell lines (royan h1) were used to produce embryoid bodies. differentiation carried out by growth factor-mediated sel...