Plasma digoxin concentrations are increased by the coadministration of anticholinergic drugs, such as propantheline, which decrease gastrointestinal motility. The present study evaluated the effect of imidafenacin, a novel anticholinergic drug, on the pharmacokinetics of digoxin. The effect of imidafenacin on the pharmacokinetics of digoxin was examined in 14 healthy Japanese male subjects in a...

It is known that digoxin, which is a liposoluble cardiac glycoside, is well absorbed from intestine. In the present study, the absorption rates of digoxin from rat duodenum and the proximal and terminal parts of small intestine were determined in vitro. The isolated everted duodenum and intestinal sacs were put into oxygenated Tyrode solution at 37 degrees C. The Tyrode solution on the outer, m...

The proarrhythmic potential of digoxin, administered in a therapeutic dosage regimen, was evaluated in conscious dogs in the subacute phase of myocardial infarction. In this evaluation, digoxin (0.0125 mg/kg/day intravenously) or vehicle were administered to conscious dogs for periods of 5 to 7 days, commencing 4 to 5 days after anterior myocardial infarction. Before treatment, programmed ventr...

The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...

This method for assaying digoxin in serum with improved specificity combines small-column extraction of serum, "high-performance" liquid chromatography, and RIA of the eluted fractions. Analytical recoveries of 1.0, 0.5, and 0.1 microgram/L standards were 95%, 93%, and 84%, respectively. The CVs for duplicates and replicates of sera with values of 0.5 to 1 microgram/L were 4 to 6%. Fifty-nine s...

The influence of potassium deficiency on myocardial H-digoxin concentration in the mouse was studied. Tritiated digoxin, 400 /Ag/kg, was injected intraperitoneally into mice, which were killed at varying time intervals, and the "H-digoxin was extracted. One-half of the mice were made potassium deficient by a diet free of potassium. In control animals, myocardial H-digoxin was maximal by 30 min ...

Digoxin is a drug commonly used to achieve rate control in heart failure and atrial fibrillation with some form of arrhythmia. It shows positive inotropic effect by inhibiting the Na + / K ATPase pump myocardial cell membrane. Since digoxin narrow therapeutic range, dose range should be monitored individual regimen established, taking care plasma concentrations. Factors such as patient's age, r...

Endogenous digoxin-like immunoreactive substance (DLIS) was first reported in volumeexpanded dogs. Its presence has been confirmed in blood, urine, and other body fluids. Elevated DLIS concentrations are encountered in patients with volume-expanded conditions such as uremia, essential hypertension, liver disease, and preeclampsia. DLISs cross-react with antidigoxin antibodies and falsely elevat...

background: atrial fibrillation (af) is one of the most common arrhythmias after coronary artery bypass graft (cabg) surgery. af can result in hemodynamic instability, thromboembolic events, increase the perioperative myocardial infarction, congestive heart failure, stroke, more length of hospital stay (lohs) and cost of treatment. the aim of this study was to evaluate the independent effect of...

The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d, p.o.) on digoxin pharmacokinetics and intestinal transport has been assessed. After intravenous or oral digoxin dosing the arterial and hepatic portal vein (oral) AUC(0-24h) were significantly reduced by PCN pre-treatment. Biliary digoxin clearance increased 2-fold following PCN treatment. PCN signif...