The wound healing activity of ethanol extract of Terminalia bellirica Roxb. fruit was evaluated on excision and incision wound model, in albino rats, in the form of an ointment with two concentrations (2 and 4% w/w ointment) of fruit extract in simple ointment base. Both concentrations of the ethanol extract showed significant response in both the wound types tested when compared with the contr...

BACKGROUND Diltiazem hydrochloride is a commonly prescribed benzothiazepine calcium channel blocker for the treatment of cardiovascular disease. Recently, 8 cases of diltiazem-induced photodistributed hyperpigmentation occurring predominantly in elderly African American women were reported. Here, we report occurrence for the first time in a light-skinned African American woman and a Hispanic wo...

Spider web is being used in India and other countries to promote wound healing. Its ointment at 2.5 and 5% w/w concentrations was tested for wound healing activity in excision and incision wound models in rats. A significant reduction in the area of excision wound was observed for both the treatments when compared to normal healing and control ointment treatments. The period of epithelization f...

Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation We thank Dr Tsuda1 for the important remark and his interest in our work. Unfortunately, we did not perform measurements on the effect of diltiazem on sympathetic nerve activity in our study and as mechanism of action of the drug we observed some direct inhibitory action on the inflammatory activity of cultu...

To determine the effects of diltiazem, a new calcium antagonist, on myocardial ischemia, two experiments were performed. The results showed 1) the intravenous holus injection of large doses of diltiazem reduced ST segment elevation in open-chest dogs with acute coronary occlusion. The regional myocardial blood flow in the control area, as well as moderately and mildly ischemic areas increased s...

Adult and pediatric patients (n = 347) with atopic dermatitis enrolled in three multicenter, randomized, 6-week studies who had previously used steroids were analyzed to examine the null hypothesis that improvement in atopic dermatitis initiated after prior treatment with steroids eliminates any subsequent treatment differences between tacrolimus ointment and pimecrolimus cream. Of these patien...

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

BACKGROUND To compare the safety and efficacy of loteprednol etabonate ophthalmic ointment 0.5% (LE ointment), a new topical ointment formulation, with vehicle for the treatment of inflammation and pain following cataract surgery. METHODS Two randomized, multicenter, double-masked, parallel-group, vehicle-controlled studies were conducted. Patients aged ≥18 years with a combined postoperative...

Kinetic parameters (k(inact) and K(I)) obtained in microsomes are often used to predict time-dependent inactivation. We previously reported that microsomal inactivation kinetic parameters of diltiazem underpredicted CYP3A inactivation in hepatocytes. In this study, we evaluated the contributions of inactivation and reversible inhibition of CYP3A by diltiazem and its N-desmethyl (MA) and N,N-did...

The purpose of this study was to determine if the known frequency-dependent effects of diltiazem on inward calcium current result in selective actions during supraventricular tachycardia. These effects were evaluated by use of an experimental model of orthodromic atrioventricular reentrant tachycardia (AVRT). AVRT was induced in 15 dogs over a wide range of retrograde conduction times before an...