This work presents a detailed numerical investigation on the required development length (L=L/B) in laminar Newtonian fluid flow microchannels with rectangular cross section and different aspect ratios (AR). The advent of new microfluidic technologies shifted practical Reynolds numbers (Re) to range unitary (and even lower) orders magnitude, i.e., creeping conditions. Therefore, accurate estima...

In this study, we described the fabrication method for microfluidic channels with circular-cross sectional geometries by reflow phenomenon. The photoresist reflow leads to shape change from rectangular to semicircular, and we optimized the reflow conditions by using positive photoresist to form the perfect cylindrical micropatterns. The resultant circular micropattern was used as a template for...

A hyperelastic pressure transducer is fabricated by embedding silicone rubber with microchannels of conductive liquid eutectic gallium–indium. Pressing the surface of the elastomer with pressures in the range of 0–100 kPa will deform the cross-section of underlying channels and change their electric resistance by as much as 50%. Microchannels with dimensions as small as 25 μm are obtained with ...

We present G23FM, a mesh generation tool for discretizing twoand three-dimensional complex fractured geological media. G23FM includes different techniques to generate finite element grids that maintain the geometric integrity of input surfaces, and geologic data and produce optimal triangular/tetrahedral grids for flow and transport simulations. G23FM generates grid for two-dimensional cross-se...

In this work, we introduce a novel method for enhanced particle filtration using shear-modulated inertial migration in straight microchannels. Depending on their size, inertial lift causes particles to migrate toward microchannel walls. Using microchannels with high aspect ratio cross sections, the fluidic shear can be modulated, resulting in preferential equilibration of particles along the lo...

A simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS) is presented and used for facil single cell trapping at low vacuums. A coating of liquid PDMS is applied on the walls of square microchannels, to give them a circular cross section. Diameters ranging from few micrometers to few hundreds of micrometers were achieved. Different coating conditions were systematicall...

Scale-up of bioengineered grafts toward clinical applications is a challenge in regenerative medicine. Here, we report tissue formation and vascularization of anatomically shaped human tibial condyles ectopically with a dimension of 20 x 15 x 15 mm(3). A composite of poly-epsilon-caprolactone and hydroxyapatite was fabricated using layer deposition of three-dimensional interlaid strands with in...

0017-9310/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.ijheatmasstransfer.2011.04.028 ⇑ Corresponding author. E-mail addresses: [email protected], maa59@ URL: http://www.mohsenakbari.com (M. Akbari). This paper outlines a novel approximate model for determining the pressure drop of laminar, singlephase flow in slowly-varying microchannels of arbitrary cross-section based on the solu...

The engineering of tissue is preferably done with stem cells, which can be differentiated into the tissue of interest using biochemical or physical cues. While much effort has been focused on using biological factors to regulate stem cell differentiation, recently interest in the contribution of physical factors has increased. In this work, three-dimensional (3-D) microchannels with topographic...