Mit Fluorbenzol als Nachbarmolekül können die Protonen des Ameisensäure-Dimers durch Quantentunneln transferieren, so wie sie es im reinen Ameisensäure-Dimer tun. einem kombinierten experimentellen und theoretischen Ansatz ermitteln Weixing Li, Denis S. Tikhonov Melanie Schnell in ihrer Zuschrift auf 25878 den folgenden Mechanismus: Das benachbarte beeinflusst nicht Reaktionsbarriere, sondern v...

Human fibrinogen is a dimer, and each half-molecule is composed of three different polypeptides (A alpha, B beta, and gamma). The two half-molecules are joined together at the amino-terminal ends by three symmetrical disulfide bonds between adjacent A alpha chains, at position 28, and between adjacent gamma chains at gamma 8 and 9. To determine the role of these disulfide bonds in fibrinogen as...

UDP-glucose dehydrogenase (UGDH) provides precursors for steroid elimination, hyaluronan production, and glycosaminoglycan synthesis. The wild-type UGDH enzyme purifies in a hexamer-dimer equilibrium and transiently undergoes dynamic motion that exposes the dimer-dimer interface during catalysis. In the current study we created and characterized point mutations that yielded exclusively dimeric ...

BACKGROUND Although complex scores were recommended for diagnosis of pulmonary embolism (PE), acceptance in clinical practice is limited. In our Emergency Department a symptom-based algorithm for patients with suspected PE including computed tomographic pulmonary angiography (CTPA) and D-dimer testing was implemented. PATIENTS AND METHODS The cases of 492 patients presenting with either chest...

A 1,4-addition of a dichlorogermylene dioxane complex with α,β-unsaturated imine 1 gave a dichlorogermane derivative 2 bearing a GeC₃N five-membered ring skeleton. By reducing 2 with KC₈, cyclic (alkyl)(amino)germylene 3 was synthesized and fully characterized. Germylene 3 readily reacted with TEMPO, N₂O and S₈, producing the 1:2 adduct 4, the oxo-bridged dimer 5 and the sulfido-bridged dimer 6...

This work explores thoroughly the reaction network of the partial oxidation of phenylmethanol at the TiO(2)-solvent interface under photocatalytic conditions by using a first-principles continuum solvation method. We demonstrate that the photocatalytic oxidation of phenylmethanol has a complex reaction network with dual pathways. The dimer pathway dominates the mechanism under aerobic condition...

introduction: elevated levels of crp are present among patients at risk for further first-ever myocardial infarction and stroke. it has been shown that after ischemic stroke, increased levels of crp are associated with unfavorable outcomes. methods: from 120 patients admitted to the emergency unit of our hospital with the diagnosis of stroke crp, d-dimer and ferritin level was measured and the ...

this paper is a density functional theory (dft) calculation of intramolecular proton transfer (ipt) in 6-hydroxypicolinic acid (6hpa, 6-hydroxypyridine-2-carboxylic acid) tautomeric forms. the transition state for the enol-to-keto transition is reported in the gas phase and in four different solvents. the planar and non-planar dimer forms of 6hpa keto and enol, respectively, were also studied i...

Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca²⁺ was not necessary for dimerization, although it greatly stabilized the protein-protein complex.