The additive-free tetrazine/enol ether click reaction was performed in ultra-high vacuum (UHV) with an enol group covalently linked to a silicon surface: Dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate molecules were coupled the of functionalized cyclooctyne which adsorbed on (001) surface via strained triple bond cyclooctyne. observed at substrate temperature 380 K by means X-ray photoelectron sp...

In this work, an efficient and green procedure for the synthesis of dihydro-2-oxypyrroles has been developed. One-pot four-component condensation reaction of aniline derivatives (2 mmol), dialkyl acetylene dicarboxylate (1 mmol), and aldehydes ( 1 mmol) was done in ethanol at 65 °C in the presence of nano-Fe3O4@SiO2/SnCl4 as a magnetically reusable he...

The following acetylenic substrates have been shown to mediate NADPH-dependent loss of cytochrome P450 on incubation with hepatic microsomes from phenobarbital-pretreated rats: 1-ethynylcyclohexanol, 1ethynylcyclopentanol, 3-methyl-1-pentyn-3-01, norethisterone, (1-methoxycyclohexyl)acetylene, 3-(2,4-dichlorophenoxy)-1-propyne, 3-(4-nitrophenoxy)-l-propyne, 3-phenoxy-l-propyne, 4-phenyl-l-butyn...

The thermal reaction of trans-1-methyl-2,3-diphenylaziridine (trans-1a) with aromatic and cycloaliphatic thioketones 2 in boiling toluene yielded the corresponding cis-2,4-diphenyl-1,3-thiazolidines cis4 via conrotatory ring opening of trans-1a and a concerted [2þ 3]-cycloaddition of the intermediate (E,E)-configured azomethine ylide 3a (Scheme 1). The analogous reaction of cis-1a with dimethyl...

A simple, efficient and eco-friendly procedure for the selective monohydrolysis of diethyl 2,6-dimethyl-4-aryl-4H-pyran-3,5-dicarboxylates under quaternary ammonium salt catalysis conditions is presented. The catalytic activities of various quaternary ammonium salts were investigated using different molar ratios of NaOH and water-organic solvent mixtures. The results indicate that the combinati...