نتایج جستجو برای: dipodal chelator
تعداد نتایج: 3695 فیلتر نتایج به سال:
Iron chelators belonging to three distinct chemical families were assessed in terms of their physicochemical properties and the kinetics of iron chelation in solution and in two biological systems. Several hydroxypyridinones, reversed siderophores, and desferrioxamine derivatives were selected to cover agents with different iron-binding stoichiometry and geometry and a wide range of lipophilici...
Gallium-68 (68Ga) is a positron-emitting isotope used for clinical PET imaging of peptide receptor expression. 68Ga radiopharmaceuticals used in molecular PET imaging consist of disease-targeting biomolecules tethered to chelators that complex 68Ga3+. Ideally, the chelator will rapidly, quantitatively and stably coordinate 68Ga3+ at room temperature, near neutral pH and low chelator concentrati...
five CQ-treated mice, and two showed no measurable Alzheimer -Amyloid Plaques A in the pellet fraction and no detectable A pathology by immunocytochemistry. The authors then examined the effects of a higher dose (30 mg/kg/d) for 9 weeks in older 21-month-old mice (n ϭ 20) as compared to Transgenic mice developing -amyloid (A) plaques sham-fed mice (n ϭ 19). This resulted in a 41% decrease ...
As Brittenham’ has reviewed in detail, the use of the oral iron chelator LI has been associated with significant clinical and animal toxicity. One of the more controversial issues surrounding the human use of LI has been the possible development of autoimmune phenomena as manifested by development of autoantibodies such as antinuclear antibodies (ANA). The Canadian group investigating LI did no...
Natural Cell Patches In article number 2212748, Longjiang Zhang and co-workers report a multifunctional nanoplatform cRGD-PEG-MNP (RpMP). RpMPs act like cell patches to suppress macrophage pyroptosis, thus potently ameliorating the development of atherosclerosis via targeting plaque neovascularization. Chelator-free Gd3+-RpMPs exhibit persistent T1-weighted contrast-enhanced efficiency resident...
The synthesis, copper(II) complexation and biotin conjugation of a bifunctional chelator incorporating a cross-bridged macrocycle are described.
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