The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.

The asymmetric unit of the title compound, [Ru(C(13)H(9)N(3))(C(15)H(11)N(3))(H(2)O)](PF(6))(2)·1.5C(3)H(6)O, consists of two crystallographically independent Ru(II) complexes. Each complex is approximately octa-hedral with the Ru(II) atom bound by an N,N'-coordinated 2-(2-pyrid-yl)-1,8-naphthyridine (pynp) ligand, a meridional 2,2':6',2''-terpyridine (tpy) ligand and one aqua ligand. The tpy l...

A DFT investigation into the mechanism for the decomposition of Grubbs 2nd generation pre-catalyst (2) in the presence of methanol, is presented. Gibbs free energy profiles for decomposition of the pre-catalyst (2) via two possible mechanisms were computed. We predict that decomposition following tricyclohexylphosphane dissociation is most favoured compared to direct decomposition of the pre-ca...

The kinetics of the ruthenium-promoted cis,cis to trans,trans isomerization of 1,1,2,2,5,5,6,6-octamethyl-1,2,5,6-tetrasilacycloocta-3,7-diene were investigated. Incubation of a ruthenium alkylidene complex, (Cy(3)P)RuCl(2)(==CHPh)Ru(p-cymene)Cl(2), in CD(2)Cl(2) for 5 days at 40 degrees C afforded a catalytically active ruthenium species that was shown to be responsible for promoting the isome...

The objective of this study is to evaluate the influence different periods abstinence on conventional sperm parameters, DNA integrity and oxidative stress. A prospective comparative that was performed between March 2018 2021. total 449 human semen samples were obtained from patients performing an advanced exploration at a private ART clinic. Exclusion criteria included azoospermia. Sperm parame...

Thirteen-week subchronic toxicity studies of direct blue 6, direct black 38, and direct brown 95 dyes were conducted by administering the test chemicals in feed to Fischer 344 rats and B6C3F1 mice. Groups of 10 rats and 10 mice of each sex were administered one of the three dyes at one of five concentrations for 13 weeks and then necropsied, beginning the second day after the end of the dosing ...

The 77 K emission spectral maxima of bis(bipyridine)ruthenium(II) complexes are found to approach a limit at energies below about 14,000 cm(-1). There is also evidence for related low-energy excited-state limits in some other classes of ruthenium polypyridyl complexes. The shapes of the vibronic sidebands found in these limits differ from those of complexes that emit at higher energies. These l...

The Z-selective ethenolysis activity of chelated ruthenium metathesis catalysts was investigated with experiment and theory. A five-membered chelated catalyst that was successfully employed in Z-selective cross metathesis reactions has now been found to be highly active for Z-selective ethenolysis at low ethylene pressures, while tolerating a wide variety of functional groups. This phenomenon a...

The photodegradation of Direct Blue 258, a member of the group of azo dyes which are commonly used in the various branches of the industry, was studied. The photostability of this dye was not previously surveyed. Photocatalytic degradation method was evaluated. The both light source include solar simulated (UV 400 W lamp) and sun light (E= 400 W/m2) and titanium dioxide nanoparticles were used ...