نتایج جستجو برای: disaggregate
تعداد نتایج: 1016 فیلتر نتایج به سال:
Abstract A trivial case in input–output structural decomposition analysis is a of product variables, or factors, where one factor an inverse—typically, Leontief inverse—of sum other factors. There may be dozens and hundreds such factors that describe the changes subsets technical coefficients. The existing literature offers ambiguous guidance this case. solution consistent with index number the...
This paper explores the development of an integrated urban-ecological simulation framework by linking two lines of urban and ecological simulation modeling. We propose a framework for linking the UrbanSim Model and the Urban Ecosystem Model, and describe the structure of the proposed approach. The model is object-oriented and links urban actors to ecological processes through a disaggregate spa...
Proteopathies are a large and diverse group of human diseases that are caused by protein misfolding. Well-known examples of proteopathies are Alzheimer's and Parkinson's disease, which are both linked to amyloid fibril formation. In this issue of Chemistry & Biology, Castellano et al. (2015) describe the way to harness the power of a protein from baker's yeast, Hsp104, to disaggregate the fibrils.
IN TESTS OF PLATELET FUNCTION IN NORMAL SUBJECTS, THE FOLLOWING RELATIONSHIPS WERE FOUND: the greater the platelet adhesiveness the less the ability to disaggregate after challenge with adenosine diphosphate (ADP), and the greater the disaggregation after ADP, the longer the clotting time in the test for platelet factor 3 availability. Such correlations were disturbed in uraemic patients.
The aggresome is an organelle that recruits aggregated proteins for storage and degradation. We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2. Depletion of RuvbL1 or RuvbL2 suppressed aggresome formation and caused buildup of multiple cytoplasmic aggregates. Similarly, downregulation of RuvbL or...
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