A 57-year-old right-handed glass-blower presented with a penetrating injury to the hypothenar eminence of his left hand sustained as he was tapping the bulb to dislodge air bubbles while making a mercury thermometer. The hypothenar eminence was swollen with a small puncture wound 3 cm from the distal wrist crease. There was no tendon or neurovascular damage. A radiograph showed multiple subcuta...

The aim of the present study was to utilize a strain gauge, which enabled the force applied to produce firmly attached crimpable hooks to rectangular stainless steel arch wires, to be measured. In vitro testing of two hooks, American Orthodontic (AO) and TP Orthodontic (TP), and two dimensions of stainless steel archwire, 0.019 x 0.025 and 0.018 x 0.025-inch, was carried out using an Instron Un...

The nucleotide triphosphate (NTP)-driven translocation hypothesis posits that NTP substrates bind to templated DNA sites prior to translocation into the active site. By using millisecond phase kinetics, we demonstrate this prediction in three different ways. First, we show that, in the presence of the translocation blocker alpha-amanitin, NTPs (but not deoxynucleotide triphosphate [dNTPs]) temp...

14CO2 capture is commonly used to evaluate the cellular oxidation rate of respiratory substrates. A modification of the established 14CO2-capture method was developed that enables the use of cells in adherent culture and easy analysis of multiple samples under different culture conditions. The use of commercially available culture and filter plates designed for use in a multiplate scintillation...

Bcl-2 can be converted into a proapoptotic molecule by nuclear receptor Nur77. However, the development of Bcl-2 converters as anticancer therapeutics has not been explored. Here we report the identification of a Nur77-derived Bcl-2-converting peptide with 9 amino acids (NuBCP-9) and its enantiomer, which induce apoptosis of cancer cells in vitro and in animals. The apoptotic effect of NuBCPs a...

The possible mechanisms by which CD4+ T cells prevent the dissemination of Cryptococcus neoformans from the primary site of infection in the respiratory tract were examined. It was found that even before fungicidal mechanisms are fully induced in the lungs, the host generates a CD4+ T cell-dependent inflammatory response that sequesters yeast within the pulmonary alveoli. This confinement is ev...

We extend the model of surface granular flow proposed in [1] to account for the effect of an external ‘wind’, which acts as to dislodge particles from the static bed, such that a stationary state of flowing grains is reached. We discuss in detail how this mechanism can be described in a phenomenological way, and show that a flat bed is linearly unstable against ripple formation in a certain reg...

Abrasive water jet (AWJ) milling process, though being an effective alternative to conventional machining for difficult-to-machine materials, induces abrasive embedment which is issue repair application by structural bonding. In this context, the effectiveness of cleaning Ti6Al4V specimens Plain Water Jet (PWJ) post AWJ studied. For this, are milled process with varying parameters create severa...

<p>In the management of regulation volumes water resource projected for a variety benefits (hydroelectric uses, irrigation, drinking water, among others), it is essential to calculate morphometric variables reservoirs anticipate changes in their morphology and predict how these could affect achievement. In this document, taking into consideration fundamental concepts Integral Calculus, de...

Female rejections of males are crucial events in sexual selection by female choice and sexually antagonistic coevolution, but there are few detailed studies of the process of rejection. Female struggles when mounted by males are often assumed to function to dislodge the male. But this study, in which female receptivity was manipulated by using females of different ages, showed that this “dislod...