The present work was conducted on the effect of surfactant on the dissolution rate of ibuprofen tablets. The cationic (Cetyl Trimethyl bromide) and anionic (Sodium dodecyl sulphate) surfactant present in the dissolution media have remarkable effect on the dissolution rate of Ibuprofen. Maximum dissolution was obtained in the presence of anionic surfactant (Sodium dodecyl sulphate) at 0.5% conce...

PURPOSE This study describes the development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets using an HPLC method. METHOD The appropriate conditions were determinate after testing sink conditions, dissolution medium, and agitation intensity. The apparatus, paddle and basket, were applied to tablets and capsules, respectively. Fexofenadine hydroch...

ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (peg), polyvinylpyrrolidone (pvp), eudragit rs po, eudragit rl po and hydroxypropylmethylcellulose (hpmc) as carriers to improve physicochemical characteristics of ibuprofen. the prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissolution be...

In this paper, we introduce a new entropy-like invariant, named Hausdorff metric entropy, for finitely generated semigroups acting on compact metric spaces from a set-valued view and study its properties. We establish the relation between Hausdorff metric entropy and topological entropy of a semigroup defined by Bis. Some examples with positive or zero Hausdorff metric entropy are given. Moreov...

In this paper, we show that in order to obtain the Tsallis entropy rate for stochastic processes, we can use the limit of conditional entropy, as it was done for the case of Shannon and Renyi entropy rates. Using that we can obtain Tsallis entropy rate for stationary Gaussian processes. Finally, we derive the relation between Renyi, Shannon and Tsallis entropy rates for stationary Gaussian proc...

Biorelevant in vitro dissolution is a useful technique for qualitative forecasting of the in vivo behavior of a formulation. A biorelevant dissolution medium for simvastatin was developed with a lower concentration of surfactant (0.1% sodium lauryl sulfate, SLS) in the medium as compared with the 0.5% SLS concentration stated in the USP monograph. The slower dissolution rate of simvastatin tabl...

In this paper, we obtain the Rényi entropy rate for irreducible-aperiodic Markov chains with countable state space, using the theory of countable nonnegative matrices. We also obtain the bound for the rate of Rényi entropy of an irreducible Markov chain. Finally, we show that the bound for the Rényi entropy rate is the Shannon entropy rate.

In this study, Al0.5CoCrFe1.5NiTi0.5 high-entropy alloy was heat-treated from 500 °C to 1200 for 24 h investigate age-hardening phenomena and microstructure evolution. The as-cast alloy, with a hardness of HV430, exhibited dendritic structure comprising an (Fe,Cr)-rich FCC phase (Ni,Al,Ti)-rich B2 phase, the interdendrite spinodal decomposed BCC phase. Age hardening softening occurred at 800 90...