Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by 1H-NMR and HRMS, their biological activity was evaluated by in vitro and in vivo studies. The in vitro binding assay and cAMP accumulation assay ...

Water extract of the leaves of Coleus Aromaticus Benth was tested for its diuretic activity in male albino rats. The study was carried out on normal rats using furosemide as a standard reference drug. Rats were treated with furosemide (4 mg/kg. p.o) and Coleus aromaticus (0.5 g/kg and 1.0 g/kg, p/o). Urine was collected and its volume was recorded. Urinary levels of sodium, potassium and chlori...

ABSTRACT. The aim of the current study was to analyze polyphenols and determines antioxidant, analgesic diuretic properties methanolic extract C.speciosus rhizome. DPPH ferric reducing antioxidant power (FRAP) assays were used determine activity. Acetic acid-induced writhing formalin-induced licking experiments assess effect. total phenolic, flavonoid flavonol contents found 51.73± 0.25 mg GAE/...

Purpose: To evaluate the diuretic activity and acute toxicity profile of the crude aqueous extract of Achyranthes aspera using animal models. Methods: Albino rats of either sex were divided into five groups (six animals in each group). The control group received normal saline (10 ml/kg), the reference group received furosemide (10 mg/kg) and the test groups were administered different doses of ...

BACKGROUND Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab has reported AZA putatively modulated AQP1. Aim of this study is to testify our hypothesis that r...

  Introduction: Urinary obstructive disease is one of the most common disorders in urinary system. Dilatation which is detected by sonography, is a key finding in obstruction in most of the cases, also could be found following surgery, lithotripsy and vesico–urethral reflux. Radioistope diuretic washout renography is a useful method to differentiate mechanical and non...