نتایج جستجو برای: dmc1
تعداد نتایج: 335 فیلتر نتایج به سال:
Biochemical form is shaped by biological function. Biochemical investigation of enzymes involved in eukaryotic homologous genetic recombination now is progressing rapidly, having only recently been inaugurated with the study of Rad51 protein, a homolog of the bacterial RecA protein. A significant new front is opened with the first report on the in vitro activities of a second and meiosis-specif...
Early meiotic nodules (also called recombination nodules) are proteinaceous structures about 100 nm in diameter that are associated with forming synaptonemal complexes (SCs) during early prophase I of meiosis. Although their function is unknown, early nodules may be involved in searching for DNA homology before synaptic initiation. Two potential components of early nodules are Rad51 and Dmc1 pr...
Orderly chromosome segregation during the first meiotic division requires meiotic recombination to form crossovers between homologous chromosomes (homologues). Members of the minichromosome maintenance (MCM) helicase family have been implicated in meiotic recombination. In addition, they have roles in initiation of DNA replication, DNA mismatch repair and mitotic DNA double-strand break repair....
Recent studies in budding and fission yeasts have revealed Mei5 and Sae3 as factors necessary for the proper function of the recombinases Dmc1 and Rad51 in DNA repair and meiotic recombination, providing new insights into how strand exchange proteins are directed along specific recombination pathways.
Bacterial RecA and its yeast orthologue RAD51 are the founding members of the RecA/RAD51 protein family, which plays a crucial role in DNA repair by homologous recombination (for review see Kawabata et al., 2005). After DNA ends are resected at the site of a DNA break, these proteins form a nucleoprotein fi lament on the single-stranded DNA and catalyze a strand invasion and strand exchange rea...
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