The physicochemical effects of the solvent DMSO on protein confirmation remain enigmatic despite its diverse applications in the proteomics field. Many attempts to understand the effects of DMSO have focused on the unfolding of a-helical-rich proteins; however, the cause of the profound stability of bsheets in DMSO remains to be elucidated. Therefore, we designed an octapeptide as a b-hairpin f...

Diaryliodonium salts are useful arylating reagents that have been exploited widely. In this Communication, we demonstrate heating diphenyliodonium triflate in the solvent DMSO leads to an unexpected arylation reaction. It is postulated of at oxygen, followed by a thia-Sommelet–Hauser rearrangement, formation 2-thiomethylphenols. More substituted diaryliodonium and cyclic shown be more stable le...

The preparation of lanthanide nitrate complexes [Ln(NO3)3{L}]n (Ln3+=La, Nd, Dy) supported by the octaethyl propane-1,1,3,3-tetrayltetrakis(phosphonate) (L) chelate ligand platform is presented. Re-crystallization these compounds from DMSO/THF led to a complete replacement multidentate phosphonate ester and formation exclusively DMSO-supported species [Ln(NO3)3(DMSO)4]. relative basicity model ...

The ruthenium anticancer compound NAMI-A, imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)], is currently undergoing advanced clinical evaluation. As with other Ru(iii) chemotherapeutic candidates, interactions with human serum albumin (HSA) have been identified as a key component of the speciation of NAMI-A following intravenous administration. To characterize coordination to HSA, we have perfor...

The dynamics of dimethyl sulfoxide (DMSO)/water solutions with a wide range of water concentrations are studied using polarization selective infrared pump-probe experiments, two-dimensional infrared (2D IR) vibrational echo spectroscopy, optical heterodyne detected optical Kerr effect (OHD-OKE) experiments, and IR absorption spectroscopy. Vibrational population relaxation of the OD stretch of d...

Trophoblast giant cells are located at the maternal-embryonic interface and have fundamental roles in the invasive and endocrine phenotypes of the rodent placenta. In this report, we describe the experimental modulation of trophoblast stem cell and trophoblast giant cell phenotypes using the Rcho-1 trophoblast cell model. Rcho-1 trophoblast cells can be manipulated to proliferate or differentia...

OBJECTIVES To provide a brief overview of intravesical dimethly sulfoxide (DMSO) therapy for interstitial cystitis and offer a practical approach to patient treatment. METHODS A review of the literature and a summation of the experience with treatment of > 300 patients with DMSO at the Interstitial Cystitis Clinic, New England Medical Center. RESULTS DMSO is helpful in a significant number ...

Two new trinuclear copper(ii) complexes without end-capping ligands, (Bu4N)2[Cu(dmso)2{Cu(dnopba)(dmso)}2] () and (Bu4N)2[Cu(dmso)2{Cu(dcopba)(dmso)}2] () [dnopba = 4,5-dinitro-ortho-phenylenebis(oxamate), dcopba = 4,5-dichloro-ortho-phenylenebis(oxamate), Bu4N(+) = tetra-n-butylammonium and dmso = dimethylsulfoxide], were synthesized and their structures were determined by single crystal X-ray...

background: the memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (stz) in rats through activation of oxidative stress, is accepted as sporadic alzheimer’s disease (ad) model in most experimental studies. dimethyl sulfoxide (dmso) as a solvent is widely used in animal studies to have antioxidant effects as well. however, no report is available about dm...