Rapid and transient protein acetylation changes in response to DNA damage Comment on: Bennetzen MV, et al. Cell Cycle 2013; 12:1688–95; PMID:23656789; http://dx.doi.org/10.4161/cc.24758 Stephanie Jungmichel and Melanie Blasius; The Novo Nordisk Foundation Center for Protein Research; University of Copenhagen; Copenhagen, Denmark; Danish Cancer Society Research Center; Copenhagen, Denmark; Email...

Background: DNA damage is one of the major consequences of radiation exposure onto the biological systems. A series of compounds including flavanoids were found to render DNA protection against radiation damage. In this study we elucidated the potential of rutin and rutin hydrate to protect plasmid DNA against damage induced by irradiation. Materials and Methods: DPPH and hydroxyl radical scave...

Crude oil is enriched in polycyclic aromatic hydrocarbons (PAHs). Many PAH analogs have proved to potentially damage DNA. DNA damage can be assessed using various biomarkers to find out the degree of genotoxicity of pollutants following in vitro exposure. In this research the comet assay and micronucleus (MN) test were used to detect DNA damages and cytogenetic changes following crude oil expos...

Reliable and efficient detection of DNA damage constitutes a vital capability of human cells to maintain genome stability. Following DNA damage, the histone variant H2AX becomes rapidly phosphorylated by the DNA damage response kinases DNA-PKcs and ATM. H2AX phosphorylation plays a central role in signal amplification leading to chromatin remodeling and DNA repair initiation. The contribution o...

Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA d...

Clustered DNA damages-two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands-are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiolog...

this study aimed to investigate effects of malathion on dna breakage in the liver and gill of rainbow trout (oncorhynchus mykiss) in the laboratory condition. the experiment was performed with four concentrations of malathion, i.e. 0 (control), 0.025, 0.05 and 0.075 mg l‑1 and three replicate for nine days. the liver and gill were sampled on the first, fifth and ninth days after the start of th...