Temporal lobe epilepsies represent the most frequent form of focal epilepsies [1]. The seizures are frequently difficult to control with antiepileptic medication and eventually 30-50% of patients have to be considered as medically refractory. Epilepsy surgery can be considered as a valuable treatment option for these patients rendering 70-90% of them seizure-free [2]. Thus, exact localization o...

In Caenorhabditis elegans, germ granules called P granules are directly inherited from mother to daughter and segregate with the germ lineage as it separates from the soma during initial embryonic cell divisions. Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expressed in the maternal germline and encode proteins that localize exclusively to P granules during em...

The mysteries of early development of cortical processing in humans have started to unravel with the help of new non-invasive brain research tools like multichannel magnetoencephalography (MEG). In this review, we evaluate, within a wider neuroscientific and clinical context, the value of MEG in studying normal and disturbed functional development of the human somatosensory system. The combinat...

It is important to reduce noise in MEG measurement, since the signal to noise ratio is smaller than 1.0, even in magnetically shielded room environment. ICA is a powerful tool for noise reduction in MEG measurements. We have applied ICA to various MEG data. By using ICA, we can remove the cardiac field, power line noise and other noises from MEG data. Also, we succeeded in extracting auditory e...

Multiple exciton generation (MEG) in semiconducting quantum dots is a process that produces multiple charge-carrier pairs from a single excitation. MEG is a possible route to bypass the Shockley-Queisser limit in single-junction solar cells but it remains challenging to harvest charge-carrier pairs generated by MEG in working photovoltaic devices. Initial yields of additional carrier pairs may ...

A method is described to derive source and conductivity estimates in a simultaneous MEG and EEG source analysis. In addition the covariance matrix of the estimates is derived. Simulation studies with a concentric spheres model and a more realistic boundary element model indicate that this method has several advantages, even if only a few EEG sensors are added to a MEG configuration. First, a si...

The magnetic fields generated by eye movements are major artifacts in MEG measurements. We propose a hybrid hierarchical variational Bayesian method to remove eye movement artifacts from MEG data. Our method is an extension of the hierarchical variational Bayesian method for MEG source localization proposed by Sato et al. [Sato, M., Yoshioka, T., Kajihara, S., Toyama, K., Goda, N., Doya, K., an...

Growth restriction in utero during a period that is critical for normal growth of the brain, has previously been associated with deviations in cognitive abilities and brain anatomical and functional changes. We measured magnetoencephalography (MEG) in 4- to 7-year-old children to test if children born small for gestational age (SGA) show deviations in resting-state brain oscillatory activity. C...

Magnetoencephalography (MEG) records the magnetic field generated by electrical activity of cortical neurons. The signal is not distorted or attenuated, and it is contactless recording that can be performed comfortably even for longer than an hour. It has excellent and decent temporal resolution, especially when it is combined with the patient's own brain magnetic resonance imaging (magnetic so...

OBJECTIVE To assess the interictal epileptic discharges (IEDs) detection rate of magnetoencephalography (MEG) recordings performed in a new light-weight magnetic shielding (LMSR) concept in a large group of consecutive patients with presumed mesiotemporal lobe epilepsy (MTLE). METHODS Thirty-eight patients (23 women; age range: 6-63 years) with presumed MTLE were prospectively studied. MEG in...