Oesophageal emptying of solids was studied with a scintigraphic technique in 12 patients with insulin dependent diabetes complicated by autonomic neuropathy and in 22 control subjects. In the diabetics the acute and chronic effects of oral domperidone on oesophageal emptying and symptoms of heartburn and dysphagia were assessed. The number of swallows required to clear the oesophagus in the dia...

The low bioavailability (15%) and good solubility of Domperidone Maleate in acidic pH following oral administration favours development of a gastro retentive formulation. Gastroretentive floating matrix tablets of Domperidone Maleate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M. From the Preformulation studies for drug excipients compatibility it ...

BACKGROUND Controversies persist regarding the effect of prokinetics for the treatment of functional dyspepsia (FD). This study aimed to assess the comparative efficacy of prokinetic agents for the treatment of FD. METHODS Randomized controlled trials (RCTs) of prokinetics for the treatment of FD were identified from core databases. Symptom response rates were extracted and analyzed using odd...

Objective: The purpose of this study was to examine the clinical efficacy, tolerability, and safety Esomeprazole 20 mg + sustained release (SR) Domperidone 30mg delivered once daily in adult patients for symptomatic alleviation dyspepsia associated with GERD. Study Design: Prospective Place Duration: PIMS Hospital Islamabad. Dec 2021- May 2022 Methods: Total 97 both genders had GERD were presen...

BACKGROUND The use of mother's own breast milk during initial hospitalization has a positive impact not only in reducing potential serious neonatal morbidities but also contribute to improvements in neurodevelopmental outcomes. Mothers of very preterm infants struggle to maintain a supply of breast milk during their infants' prolonged hospitalization. Galactogogues are medications that induce l...

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

Development and Validation of RP-HPLC Method for the Simultaneous Estimation Domperidone Naproxen in Tablet Dosage FormMd. Shozan Mondal, Md. Ahsanul Haque, Mohammad Safiqul Islam, S.M. Ashraful Islam

Effect of 8 Hours of Isocapnic/Poikilocapnic Hypoxia on the Ventilatory Response to CO[subscript 2] p. 17 Ventilatory Responses to Hypoxia after 6 Hours Passive Hyperventilation in Humans p. 21 Ventilatory Effects of 8 Hours of Isocapnic Hypoxia with and without [beta]-Blockade p. 25 Modulation of Ventilatory Sensitivity to Hypoxia by Dopamine and Domperidone before and after Prolonged Exposure...