Rosai-Dorfman disease is a rare, benign presenting with extensive lymphadenopathy. In this case, an 81-year-old gentleman previous pulmonary tuberculosis, presented painless cervical lymphadenopathy associated generalized weakness, loss of appetite, and cough.

Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease (RDD), is an uncommon benign histioproliferative disorder with systemic symptoms and lymphadenopathy. Mostly affecting lymph nodes, RDD typically presents as substantial painless bilateral cervical lymphadenopathy associated with fever, leukocytosis, anemia, polyclonal hypergammaglobulinemia, and increased ery...

Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a reactive condition of unknown etiology, characterised by a proliferation of histiocytes exhibiting emperipolesis of lymphocytes and plasma cells. It usually presents as bilateral painless cervical lymphadenopathy. Extranodal RDD without nodal disease is seen in 23% of the cases. Intracranial RDD occurs in less ...

Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It rare (1:200000), particularly in children and commonly presents with massive, painless usually bilateral cervical lymphadenopathy along fever weight loss. Leukocytosis, elevated erythrocyte sedimentation rate hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis affected lymph nodes. E...