Dosage compensation, the equalized X chromosome gene expression between males and females in Drosophila, has also been found in triple X metafemales. Inverse dosage effects, produced by genomic imbalance, are believed to account for this modulated expression, but they have not been studied on a global level. Here, we show a global expression comparison of metafemales (XXX; AA) with normal femal...

Liliana M. Costa, Jing Yuan, Jacques Rouster, Wyatt Paul, Hugh Dickinson, and Jose F. Gutierrez-Marcos* (Current Biology 22, 160–165; January 24, 2012) Due to an author oversight, Table S2 in the online Supplemental Information for this article was incorrectly titled ‘‘Dosage Effects of Imprinted pBet9>synMeg1.’’ The correct title for Table S2 should be ‘‘Dosage Effects of Nonimprinted pBet9>sy...

BACKGROUND AND PURPOSE This study is to investigate the actual using patterns and clinical effects of topiramate in patients with neurosurgical disease as antiepileptic drugs (AEDs) in 94 korean multicenters. METHODS A total of 7,152 patients who had taken topiramate for at least 3 months between August 2008 and February 2009 were eligible to participate in this study. We evaluated demographi...

Although vocational schooling is responsible for educating a large share of students in the world today, there is little evidence about what factors matter for vocational student learning. Using data on approximately 1,400 vocational students in one eastern province in China, we employ a student fixed effects model to identify whether teacher enterprise experience—believed to be one of the most...

The paper empirically studies whether pharmaceutical firms uses advertising as a signal for high quality drugs. A nested random effects count data hurdle model is introduced to handle the excess number of zero observations in the sample as well as nested random drug, firm and substance specific effects. The empirical study indicate that drug quality (measured as the number of side-effects) do n...

BACKGROUND Controversy persists about the use of right unilateral (RUL) and bilateral (BL) electroconvulsive therapy (ECT). While RUL ECT results in less severe short-term and long-term cognitive effects, there is concern that it is less efficacious than BL ECT. METHODS In a double-blind study, 80 depressed patients were randomized to RULECT, with electrical dosages 50%, 150%, or 500% above t...

This paper surveys panel data methods for count dependent variable that takes nonnegative integer values, such as number of doctor visits. The focus is on short panels, as the literature has concentrated on this case. The survey covers both static and dynamic models with random and fixed effects. The paper surveys quasi-ML methods based on the Poisson, as well as richer more parametric models n...

Cisplatin is the most common antineoplastic drug used for the therapy of solid tumours. To date, researchers have focused on the dosage to be administered for each specific tumour, mainly considering the local adverse effects. The aim of this study was to correlate the severity of the adverse effects with: i) the dosage of cisplatin; ii) the speci...