We examined the effect of intramuscular injections of recombinant bovine interferon-7 on basal body temperature and plasma concentrations of progesterone in cows. Six mature, nonlactating Holstein cows were synchronized for estrus and assigned randomly to a replicated 3 x 3 Latin square design to receive 0, 1, or 5 mg of recombinant bovine interferon-7 intramuscularly on d 9, 12, or 15 of the e...

s+%26+Virtual+Meeting/Abstracts?&vmview;=abst_detail_view&confID;=47&abstractID;=33295; cited March 30, 2009]4. Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U on behalf of the Eastern Cooperative Oncology Group. A pooled analysis of Eastern Cooperative Oncology Group and Intergroup trials of adjuvant high-dose interferon for melanoma. Clin Cancer Res 2004;10:1670–7. 5. Kilbridg...

Background Intravenous acetaminophen reaches a higher mean peak plasma concentration than oral in shorter period of time. The favorable pharmacokinetics intravenous may be beneficial for treating intrapartum maternal fever. Objective primary objective was to compare and time defervescence (temperature <38°C). secondary the percentage participants being afebrile percent reduction temperature 30 ...

2-Amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166) induced high levels of circulating interferon in mice when administered either parenterally or orally. Peak titers of interferon were found in the serum between 6 and 12 h after inoculation of the drug. Lower but significant levels of interferon were found in rat serum after administration of U-25,166 by either the intraperitoneal or oral route,...

OBJECTIVE To determine the frequency and severity of leucopenia during antiviral treatment in patients with hepatitis C and the effectiveness of G-CSF (Granulocyte-Colony Stimulating Factor) in its management. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY Shafi Clinic, Rawalpindi, from July 2005 to July 2007. METHODOLOGY Patients with Polymerase Chain Reaction (PCR) pos...

INTRODUCTION Accelerated liver function deterioration has been recognized in renal transplant recipients infected with hepatitis C virus (HCV). Although combination therapy with interferon plus ribavirin has been established as the standard treatment for patients with chronic HCV, the high risk of allograft rejection associated with interferon therapy has greatly discouraged the clinical use of...

BACKGROUND Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection. The favorable CC genotype is associated with significantly higher rates of sustained virologic response. No data exist o...

At the end of 2020, population-based vaccination programs with new generation mRNA-based vaccines began almost all over world. The aim study was to evaluate titer anti-SARS-CoV-2 IgG antibodies against S1 subunit virus’s spike protein as a marker humoral response in 477 patients and concentration interferon-gamma an indicator cellular 28 individuals. In our studies, we used serological enzyme-l...

Twelve cloned viruses were randomly isolated from original (uncloned) vesicular stomatitis virus (VSV), and their sensitivities to mouse and human interferons were examined. When the interferon sensitivities of these various VSVs were compared by the plaque reduction method in L cells, virus 3 was found to be sevenfold more sensitive than virus 11, and the interferon sensitivity of the original...

Although scrapie has been studied for many years, the nature of the scrapie agent remains obscure (14). In spite of a number of unusual properties, this agent has been generally considered to be a virus (9, 13). In a previous study, repeated daily injections of 6,000 units of interferon failed to protect mice challenged intracerebrally (ic) with about 5,000 median lethal dose (LD50) of the scra...