We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl) benzenesulfonamide HCl (LSN2424100) binds with high affinity to recombinant human OX2 receptors (Ki = 4.5 nM), and selectivity over OX1 receptors (Ki = 393 nM). LSN242410...

Deep reinforcement learning (DRL) brings the power of deep neural networks to bear on the generic task of trial-and-error learning, and its effectiveness has been convincingly demonstrated on tasks such as Atari video games and the game of Go. However, contemporary DRL systems inherit a number of shortcomings from the current generation of deep learning techniques. For example, they require ver...

BACKGROUND Different target-filter combinations in computed radiography have different impacts on the dose and image quality in digital radiography. This study aims to evaluate the mean glandular dose (MGD) and modulation transfer function (MTF) of various target-filter combinations by investigating the signal intensities of X-ray beams. METHODS General Electric (GE) Senographe DMR Plus mammo...

In 2015, Google’s Deepmind announced an advancement in creating an autonomous agent based on deep reinforcement learning (DRL) that could beat a professional player in a series of 49 Atari games. However, the current manifestation of DRL is still immature, and has significant drawbacks. One of DRL’s imperfections is its lack of “exploration” during the training process, especially when working ...

Today’s large-scale services generally exploit looselycoupled architectures that restrict functionality requiring tight cooperation (e.g., leader election, synchronization, and reconfiguration) to a small subset of nodes. In contrast, this work presents a way to scalably deploy tightlycoupled distributed systems that require significant coordination among a large number of nodes in the wide are...

Neural function is dependent upon the proper formation and development of synapses. We show here that Wnt5 regulates the growth of the Drosophila neuromuscular junction (NMJ) by signaling through the Derailed receptor. Mutations in both wnt5 and drl result in a significant reduction in the number of synaptic boutons. Cell-type specific rescue experiments show that wnt5 functions in the presynap...

In this paper, we introduce a new set of reinforcement learning (RL) tasks in Minecraft (a flexible 3D world). We then use these tasks to systematically compare and contrast existing deep reinforcement learning (DRL) architectures with our new memory-based DRL architectures. These tasks are designed to emphasize, in a controllable manner, issues that pose challenges for RL methods including par...

Background: The aim of this study was to measure and determine diagnostic reference levels (DRLs) of programs used at intraoral and dent panoramic examinations in Kosovo. Materials and Methods: To determine DRL, were performed measurements for dose area product (DAP) at intraoral and dental panoramic radiology systems. This study has covered over 47% of X-ray units, which are in use for intraor...

INTRODUCTION The aim of this study was to establish institutional diagnostic reference levels (DRLs) by summarising doses collected across the five computed tomography (CT) system in our institution. METHODS CT dose data of 15940 patients were collected retrospectively from May 2015 to October 2015 in five institutional scanners. The mean, 75th percentile and 90th percentile of the dose sprea...