Rationale: The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signaling pathways, including Notch, have been implicated in this process, the rol...

RATIONALE The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signaling pathways, including Notch, have been implicated in this process, the role...

Double aortic arch (DAA) is a form of vascular ring found in approximately 1 in 2000–4000 pregnancies on fetal echocardiography. In some cases of DAA, respiratory compromise occurs during infancy due to compression of the trachea, which is completely encircled by the right aortic arch (RAA) and left aortic arch (LAA). RAA and left arterial duct were initially seen on screening fetal echocardiog...

Aortic arch anomalies in infancy often cause intrathoracic airway obstruction. Airway function was assessed as part of the diagnostic evaluation in six symptomatic infants both by plethysmography and using a chest compression technique to obtain partial flow-volume loops. Two infants had normal intrathoracic airway function and their symptoms were unrelated to aortic arch abnormalities. The rem...

Introduction Several reports on anomalies of the aortic arch concomitant with coaretation of the aorta are to be found in the literature.3 This paper describes such anomalies as they were found in two of our surgical cases, which showed unusual features not hitherto described in the literature available to us. These anomalies, although rare, are of practical importance with a view to differenti...