Novel bioresorbable fiber/microsphere composite structures loaded with proteins were developed and studied. These unique polymeric structures are designed to combine good mechanical properties with a desired controlled protein-release profile, in order to serve as scaffolds for tissue regeneration applications. The composite fiber structures were formed by "coating" poly(L-lactic acid) fibers w...

double emulsion solvent evaporation technique is one of the most attractive methods used to prepare micro and nanoparticles in pharmaceutical areas of interest, but because of the effects of many formulation factors on the size and release behavior of the fabricated particles, optimization of the formulation factors is needed. in this study various parameters including technical and composition...

The aim of this study was to evaluate intraocular biodistribution of a fluorescent polymeric nanosystem composed of chitosan and gelatin after intravitreal administration in rat eyes. The nanoparticles based on chitosan and gelatin were synthesized using a reverse emulsion-double cross-linking technique (ionic and covalent) and their structural characteristics are presented. Two units of 1% sus...

A method for the analysis of silver grain content in both single and double label autoradiographs is presented. The total grain area is calculated by counting the number of pixels at which the recorded light intensity in transmission dark field illumination exceeds a selected threshold. The calibration tests included autoradiographs with low (3H-thymidin) and high (3H-desoxyuridin) silver grain...

Proteases are industrially important enzymes but often have to be improved for their catalytic efficiency and stabilities to suit applications. Flow cytometry screening technology based on in vitro compartmentalization in double emulsion had been developed and applied on directed evolution of paraoxonase and β-galactosidase. Further advancements of flow cytometry-based screening technologies wi...

One of general free boundary problems concerning the electrohydrodynamic effects on a concentric double emulsion drop is studied theoretically for the three constituent phases of leaky dielectric fluids. In order to proceed the problem analytically, the domain perturbation procedure is utilized in the small deformation limit. The patterns of electric-field-driven flow are successfully character...

In present paper, dynamic behavior and control of a fluidized bed reactor for polyethylene production has been considered. A double active sites model for Ziegler-Natta catalysts is used for simulation of polymerization reaction. Hydrodynamic behavior of the bed is modeled using a two phase model including bubble and emulsion phases in which bubble phase has plug flow pattern with different...

STUDY OBJECTIVES Lipid emulsions have been suspected of inducing certain modifications in gas exchange and pulmonary hemodynamics. The aim of this prospective study was to evaluate the hemodynamic and pulmonary effects of two lipid emulsions. DESIGN Prospective, randomized, double-blind, crossover study. SETTING Medical and surgical ICU in a French university hospital. PATIENTS Eighteen p...

Double metal cyanides (DMCs) are highly active recyclable heterogeneous catalysts for hydroamination of phenylacetylene with 4-isopropylaniline. The best hydroamination yields are obtained with Zn-Co DMCs, especially if the particle size is decreased by a reverse emulsion synthesis technique.

This article examines the Weibull statistical analysis that was used for investigating the effect of melt filtration on tensile properties and defects formed inside the casting. Forming and entrapping of double oxide films have been explained by using the context of critical velocity of melt in the runner. SutCast software results were used to examine the amounts of the velocity of melt as...