Dowling-Degos disease (DDD) is a rare autosomal dominant trait characterized by numerous, symmetrical, progressive and pigmented macules over the axillae, groins, face, neck, arms and trunk as well as scattered comedo-like lesions (dark dot, follicles) and pitted acneiform scars. Histopathology is diagnostic testing using a distinctive form of acanthosis, characterized by an irregular elongatio...

Dowling-Degos disease is a rare autosomal dominant inherited pigmentary disorder characterized by reticulate pigmentation of the flexures, prominent comedone like lesions and pitted scars. Dyschromatosis universalis hereditaria is characterized by the presence of hypopigmented as well as hyperpigmented macules. We report a family showing features of both these diseases.

Kristin M. Holland, PhD, MPH; Christopher Jones, PharmD, DrPH, Alana Vivolo-Kantor, Nimi Idaikkadar, Marissa Zwald, PhD; Brooke Hoots, Ellen Yard, Ashley D’Inverno, Elizabeth Swedo, MD; May S. Chen, Emiko Petrosky, Amy Board, Pedro Martinez, Deborah Stone, ScD; Royal Law, Michael A. Coletta, BS; Jennifer Adjemian, Craig Thomas, Richard W. Puddy, Georgina Peacock, Nicole F. Dowling, Debra Houry,...