Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereb...

the Ottawa Hospital has introduced a dress code that will require staff to wear uniforms prescribed by their respective departments and functions. The Ontario-based hospital may be the first to issue a formal, publicized dress code in the country. Put into effect in March, the code requires staff to don their scrubs and lab coats whenever they enter the hospital, and take them off when they lea...

DRESS: drug rash with eosinophilia and systemic symptoms INTRODUCTION Vemurafenib and dabrafenib are 2 BRAF inhibitors that are approved by the US Food and Drug Administration for the treatment of metastatic malignant melanoma with BRAF mutation. These drugs improve overalland progression-free survival. Some severe vemurafenib-induced reactions have been reported, which commonly require treatme...

Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe cutaneous drug adverse reaction (SCAR) with a not well known pathogenesis. Strong genetic associations between HLA groups and drug allergy have been reported but seem to be specific for a type of SCAR, one drug and an ethnic group. Using a pangenomic approach, effective even on a small effective, by an...

We propose a method to try to model fashionable dresses in this paper. We first discover common visual patterns that appear in dress images using a human-in-the-loop, active clustering approach. A fashionable dress is expected to contain certain visual patterns which make it fashionable. An approach is proposed to jointly identify fashionable visual patterns and learn a discriminative fashion c...

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threatening syndrome characterized by skin rash, fever, lymph node enlargement, and involvement of internal organs. It is most commonly induced by aromatic anticonvulsants and antibiotics. Nonaromatic anticonvulsants are rarely encountered as the causes of DRESS syndrome. In the present report,...

TOPIC: Allergy and Airway TYPE: Global Case Reports INTRODUCTION: Severe cutaneous adverse reactions (SCARs) are a group of disorders caused by drug-induced hypersensitivity response. One important type SCAR is Drug Reaction with Eosinophilia Systemic Symptoms (DRESS) – complex, multisystem, possibly life-threatening drug Here we report case Lamictal associated DRESS which rare seldom reported....

DRESS syndrome is a severe drug induced reaction. Acute kidney injury (AKI) is sometimes present in the form of an acute interstitial nephritis. We present the case of a 75-year-old man with glioblastoma who developed a DRESS two months after starting levetiracetam and a few days after stopping dexamethasone. His skin and kidneys improved after removing levetiracetam and introducing again corti...

Various skin and systemic symptoms may develop as a complication of treatment with different medications and medicinal substances. One of them is a relatively rare drug reaction with eosinophilia and systemic symptoms, referred to as DRESS syndrome. The morphology of skin lesions and the patient's general health can differ; the management involves withdrawal of drugs suspected of triggering DRE...

Background Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an idiosyncratic hypersensitivity reaction to drugs. The diagnosis involves 3 criteria; 1) Drug induced skin eruption 2) Absolute eosinophil count (AEC) >1500/dL or atypical lymphocytosis 3) One of the following enlarged lympnodes atleast 2cm in diameter, hepatitis, interstitial nephritis, interstitial lung disease...