BACKGROUND AND THE PURPOSE OF THE STUDY Vasopressin type 2 receptor (V2R), a G protein coupled receptor (GPCR), plays an important role in the regulation of renal antidiuretic function. The highly conserved DRH motif is essential for G protein signaling of V2R; however its role especially regarding the histidin residue is not fully understood.. METHODS Site directed mutagenesis was performed ...

form of salary support for staff members (JAL and CH) and funding for RB and DRH. WHO staff members received no external funding. Members of the WHO-CHOICE team helped frame the questions for the analysis and provided guidance on standardised methods. DRH and JAS were supported by a grant (P01 AG17625) from the National Institute on Aging, which had no role in the study design, execution, or re...

Urolithiasis is defined as the formation of urolith or crystal in urinary tract caused by supersaturation urine. This study was conducted at PDHB drh Cucu Kartini S, dkk, Jakarta clinic. The data were taken from urinalysis test results 23 dogs which suffered crystaluria and stone examination 11 post cystotomy. Most affected breeds Shihtzu, Pug, Mini Pom, Corgi, Miniature Schnauzer, Golden Retri...

Study objective: Our objective is to determine the proportion of medication-related problems that lead patient admission, such as drug interactions, side effects, and abuse. The study also aims evaluate significance clinical pharmacist's contribution care follow-up regarding appropriate use safe effective treatments. Methods: This was conducted at al Basra Teaching Hospital. All 115 patients wi...

One of the basic tasks in bioinformatics is localizing a short subsequence S, read while sequencing, in a long reference sequence R, like the human geneome. A natural rapid approach would be finding a hash value for S and compare it with a prepared database of hash values for each of length |S| subsequences of R. The problem with such approach is that it would only spot a perfect match, while i...

Double-stranded RNAs are an important class of functional macromolecules in living systems. They are usually found as part of highly specialized intracellular machines that control diverse cellular events, ranging from virus replication, antiviral defense, RNA interference, to regulation of gene activities and genomic integrity. Within different intracellular machines, the RNA duplex is often f...

Female rats were exposed to 0, 0.5, or 6.4 ppm methylmercury in their drinking water before mating, and throughout gestation and lactation. When the female offspring were 4-6 months old, they were trained to respond under a multiple differential reinforcement of high rate (DRH) 9:4-- Extinction schedule of reinforcement. No differences among exposure groups were apparent in steady-state behavio...