This study was designed to investigate the effects of tangerine, orange, and grapefruit juice on the pharmacokinetic pattern of cyclosporine A in rats. Forty male Sprague-Dawley rats were divided into four groups to receive water, orange, tangerine, or grapefruit juices respectively. Water or juices (10 ml/kg) were given orally twice a day for 3 days. Three hours after the 5th dose, cyclosporin...

In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (Cmax) compared to administration with water (7.11 versus 9.10 microg/ml), slightly increased the time to Cmax (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h...

“While our findings suggest that people who consume large amounts of whole grapefruit or orange juice may be at increased risk for melanoma, we need much more research before any concrete recommendations can be made,” said lead study author Shaowei Wu, PhD, a postdoctoral research fellow at the Department of Dermatology, the Warren Alpert Medical School of Brown University in Providence, Rhode ...

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is added to grapefruit pulp the pulp acts as a bland filler and makes an apple pie. If peach is added it makes a peach pie. Citric acid, sugar and peel oil give excellent orange, grapefruit and tangerine jams. A little' peel oil, sunset yellow, No. 6 and sugar makes a good ice cream mix. Add more sugar and you have a good sundae topping. Cake fillings were made from the jams but they gave troub...

American foulbrood, caused by Paenibacillus larvae subsp. larvae (White 1906) is one of the most serious diseases of honey bees, causing beekeepers and health workers to make difficult, complex decisions and leading to the development of 'organic' treatments, such as grapefruit seed extract, with minor residue problems in the end product. This study evaluates the chemical composition of grapefr...

In Jordan, as well in all the world countries, consumption of citrus fruits is an essential part daily diet, so it important to assess potential risk persistent organic pollutants such polyaromatic hydrocarbons (PAHs) these human health and identify their sources order eliminate or reduce them. This study reports 16 priority PAHs content four types peeled grown Jordan valley. were detected stud...