In vitro dissolution methodologies that adequately capture the oral bioperformance of solid dosage forms are critical tools needed to aid formulation development. Such methodologies must encompass important physiological parameters and be designed with drug properties in mind. Two-phase dissolution apparatuses, which contain an aqueous phase in which the drug dissolves (representing the dissolu...

Evaporative precipitation of nanosuspension (EPN) was used to prepare nanoparticles of poorly water soluble drugs, namely silymarin (SLM), hesperetin (HSP) and glibenclamide (GLB), with the aim of improving their rate of dissolution. The original drugs and EPN prepared drug nanoparticles were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and dissol...

Surface solid dispersions using water-insoluble carriers like crospovidone, croscarmellose sodium, sodium starch glycolate, pre-gelatinized starch, potato starch and Avicel PH 101 were investigated to enhance the dissolution rate of the glimepiride, a poorly water insoluble drug. The effect of various carriers on dissolution profile was studied using presence absence model. The surface solid di...

Introduction Drug dissolution testing is an integral part of drug product development and quality assessment. Often drug dissolution testing is a regulatory requirement to establish the quality of a drug product [1-3]. In reality,drug dissolution testing is a solubility determination technique. It utilizes specialized equipment for that purpose,commonly known as basket and paddle apparatuses. T...

Introduction Dissolution is a characterization test commonly used by the pharmaceutical industry to guide formulation design and control product quality. Often, it is a required performance test for solid dosage forms,transdermal patches,and suspensions. It is also the only test that measures the rate of in vitro drug release as a function of time, which can reflect either reproducibility of th...

the present work was aimed to design and develop self-nanoemulsifying drug delivery systems (snedds) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having ph dependant solubility. the solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

Paracetamol (PCM) is a non-steroidal anti-inflammatory drug (NSAID), sparingly soluble and bitter in taste. It is widely used as an analgesic and antipyretic. Solid dispersion of drug with different polymers was attempted to improve solubility of paracetamol.The aim of this study was to prepare, characterize and compare solid dispersions of poorly water soluble non-steroidal anti-inflammatory d...

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract. In this work, we focused on the optimization of dissolution compartments/vessels for an updated version of the biorelevant dissolution apparatu...

The aim of this study was the development of a dissolution test with IVIVC for extended-release bromopride (BPD) pellets using bioavailability data. BPD is a Biopharmaceutics Classification System Class 2 drug, and its absorption is primarily limited by its dissolution rate. Despite this, there are no reports describing a dissolution test for BPD dosage forms. The dissolution medium was selecte...