Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulation of nanonencapsulated drug at the diseased site. This article focussed on the...

Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug carrier is poorly understood. Here, we developed a series of QSPR models to account for the drug lo...

Evaluated in this study were the effects of the two parameters, namely level of penetration enhancer and drug loading dose, on in vitro skin release of Caffeine and vitamin B5 and adhesion properties of drug in adhesive transdermal systems. In order to characterize in vitro drug release, a hydrodynamically Chien permeation system with rat abdominal skin was employed. Caffeine skin release rate ...

In this study Isoniazid (INH) as one of the first line drugs in treatment of Tuberculosis was investigated to be loaded in Solid Lipid Nanoparticles (SLNs) for reducing hepatotoxicity as well as prolonging drug release. High shear homogenization method was performed to prepare INH SLNs. To compare biodistribution of INH before and after loading in SLNs, INH was labeled by Technetium 99 (Tc99) a...

In this work, racemic hybrid polypeptides poly(ethylene glycol) (PEG)-b-poly(racemic-leucine) (PRL) copolymers with different leucine residues have been synthesized and characterized. Using docetaxel as a model molecule, the high drug-loaded spherical micelles based on PEG-PRL were prepared successfully using dialysis, with a tunable particle size from 170 nm to 250 nm obtained by changing the ...

a multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. for this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 m hcl containing nacl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by hot homogenisation and a solvent-free method. The optimum griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, such as high pressure homogenisation (HPH) parameters, lipid and surfactant screening and selection of suitable lipid to surfactant ratios; followed by photon correlation stu...

in the present study, sodium alginate microparticle for oral delivery of furosemide was designed whether the encapsulation into microparticles might improve the oral absorption of this potent loop diuretic. we described preparation of microspheres based on ionotropic gelation method and characterized its physicochemical properties. to acquire an optimum formulation, a generalized regression neu...

Purpose: To evaluate the mechanism of drug release of a slightly soluble drug (theophylline) from nanocomposite of zeolite (ZLT) or hydrotalcite (HTC) used as drug carrier. Methods: Nanocomposite was prepared with dispersion of either ZLT or HTC as drug carrier and theophylline (THP) as drug in drug to clay ratios of 1:2, 3:4 and 1:1. The formulations were characterized for drug release and loa...