Conventional chemotherapy for the treatment of cancer has limited specificity when administered systemically and is often associated with toxicity issues. Enhanced accumulation of polymeric nanocarriers at a tumor site may be achieved by passive and active targeting. Incorporation of trigger responsiveness into these polymeric nanocarriers improves the anticancer efficacy of such systems by mod...

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

A multifunctional gold nanorod (GNR)-based nanoplatform for targeted anticancer drug delivery and positron emission tomography (PET) imaging of tumors was developed and characterized. An anti-cancer drug (i.e., doxorubicin (DOX)) was covalently conjugated onto PEGylated (PEG: polyethylene glycol) GNR nanocarriers via a hydrazone bond to achieve pH-sensitive controlled drug release. Tumor-target...

A variety of nanocarriers such as bioconjugates, dendrimers, liposomes, and nanoparticles have been widely evaluated as potential targeted drug delivery systems. Passive targeting of nanoscale carriers is based on a size-flow-filtration phenomenon that is usually limited to tumors, the reticular endothelial system, and possibly lymph nodes (LNs). In fact, targeting the delivery of drugs to pivo...

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such pH, redox agents, light or temperature.

Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic-organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injec...

T he unique geometry of carbon nanotubes allows them to be used as drug-delivery vehicles or ‘nanocarriers’ in cancer therapy and other areas of medicine1. Nanocarriers work by bringing drugs directly to diseased areas of the body, thereby minimizing the exposure of healthy tissues while increasing the accumulation of the drug in the tumour area. This reduces both the dose necessary for treatme...

In last few decades, there has been a considerable research interest in the area of drug delivery using polymer based particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles and micelles have been used as a physical approach to alter and improve the pharmacodynamic and pharmacokinetic profiles of various types of drug molecules. Due to the ...

The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of pharmaceutical actives. The attempts to overcome the low solubility and bioavailability of some drugs by their incorporation into lipid nanocarriers have been summarized. A special focus of this review is on different routes of ad...